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Table 1 Insulin glargine dose titration algorithm and monitoring

From: Clinical study of treatment switching from premixed insulin to basal insulin combined with oral hypoglycemic drugs in patients with type 2 diabetes

Insulin dose titration algorithm

If self-monitored fasting BG for 2 consecutive days with no severe hypoglycemia:

 
 

> 8.9 mmol/l (> 160 mg/dl)

Add 8 IU/day

 

>7.8 to ≤ 8.9 mmol/L(>140 to ≤160 mg/dl)

Add 6 IU/day

 

>6.7 to ≤ 7.8 mmol/L(>120 to ≤140 mg/dl)

Add 4 IU/day

 

>5.5 to ≤ 6.7 mmol/L(>100 to ≤120 mg/dl)

Add 2 IU/day

 

5.5 mmol/l (≤100 mg/dl)

No further