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Table 2 Relationship of the tertile of serum sRAGE with the prevalence of MetS in men (n = 712) a

From: Higher serum soluble receptor for advanced glycation end product levels and lower prevalence of metabolic syndrome among Japanese adult men: a cross-sectional study

  Tertiles of serum sRAGE  
Median, interquartile range (pg/mL) Low (n = 238) Middle (n =237) High (n =237) P for trendb
  (847.6, 710.0–950.0) (1259.1, 1152.8–1377.2) (1835.0, 1608.9–2107.8)  
MetS     
 Crude 1.00 0.85 (0.57–1.27) 0.47 (0.31–0.73) <0.001
 Model 1c 1.00 0.89 (0.59–1.35) 0.45 (0.28–0.71) 0.001
 Model 2d 1.00 1.04 (0.67–1.61) 0.58 (0.36–0.95) 0.038
Central obesity     
 Crude 1.00 0.88 (0.60–1.29) 0.37 (0.24–0.57) <0.001
 Model 1c 1.00 0.86 (0.58–1.27) 0.33 (0.21–0.52) <0.001
 Model 2d 1.00 0.96 (0.64–1.45) 0.41 (0.25–0.66) <0.001
 Model 3e 1.00 0.99 (0.65–1.52) 0.46 (0.28–0.75) 0.003
Elevated BP     
 Crude 1.00 0.55 (0.38–0.80) 0.33 (0.22–0.48) <0.001
 Model 1c 1.00 0.61 (0.40–0.93) 0.38 (0.25–0.57) <0.001
 Model 2d 1.00 0.66 (0.43–1.02) 0.45 (0.29–0.70) <0.001
 Model 3e 1.00 0.65 (0.42–1.01) 0.49 (0.31–0.77) 0.002
Elevated FBG     
 Crude 1.00 1.01 (0.69–1.48) 0.70 (0.47–1.04) 0.078
 Model 1c 1.00 1.17 (0.78–1.75) 0.89 (0.58–1.37) 0.64
 Model 2d 1.00 1.21 (0.81–1.84) 0.97 (0.63–1.51) 0.95
 Model 3e 1.00 1.29 (0.85–1.96) 1.20 (0.76–1.89) 0.40
Elevated TG     
 Crude 1.00 1.01 (0.69–1.47) 0.68 (0.46–1.03) 0.054
 Model 1c 1.00 1.00 (0.68–1.48) 0.62 (0.41–0.93) 0.024
 Model 2d 1.00 1.11 (0.74–1.65) 0.75 (0.49–1.65) 0.19
 Model 3e 1.00 1.17 (0.77–1.77) 0.85 (0.54–1.33) 0.50
Reduced HDL-C     
 Crude 1.00 0.91 (0.54–1.52) 0.94 (0.56–1.57) 0.81
 Model 1c 1.00 0.77 (0.44–1.33) 0.63 (0.36–1.11) 0.11
 Model 2d 1.00 0.88 (0.45–1.56) 0.87 (0.46–1.56) 0.65
 Model 3e 1.00 0.85 (0.47–1.53) 0.90 (0.48–1.68) 0.74
  1. aData are odds (95% confidence interval). sRAGE, soluble receptor of advanced glycation end-products; MetS, metabolic syndrome.
  2. bMultiple logistic regression analysis.
  3. cAdjusted for age (continuous variable), smoking status (never, former, or current), drinking status (never, ≤ 3 day(s)/week, 4–6 days/week, or every day), educational level (≥college or not), occupation (desk work or non-desk work), depressive symptoms (Self-Rating Depression Scale ≥40 or not), physical activity (<1.0 METs · hour/week, 1.0–22.9 METs · hour/week, or ≥23.0 METs · hour/week), total energy intake (continuous variable), sleep time (≥6 and ≤8 hours/day or not), and eGFR (continuous variable).
  4. dAdditionally adjusted for serum high sensitivity C-reactive protein concentration (continuous variable).
  5. eAdditionally adjusted for mutual metabolic syndrome components.