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Table 1 Characteristics of the participants according to the tertiles of serum sRAGE in men (n = 712) a

From: Higher serum soluble receptor for advanced glycation end product levels and lower prevalence of metabolic syndrome among Japanese adult men: a cross-sectional study

  Tertiles of serum sRAGE
Median, interquartile range (pg/mL) Low (n = 238) Middle (n =237) High (n =237) P for trendb
  (847.6, 710.0–950.0) (1259.1, 1152.8–1377.2) (1835.0, 1608.9–2107.8)  
Age (years) 51.0 (41.0–57.0) 46.0 (38.0–56.0) 44.0 (38.0–54.0) <0.001
BMI (kg/m2) 24.5 (22.3–26.1) 23.7 (21.7–26.1) 22.7 (20.9–24.4) <0.001
WC (cm) 86.0 (81.0–92.0) 85.0 (79.0–92.0) 82.0 (77.0–87.0) <0.001
SBP (mmHg) 133.0 (122.0–143.0) 130.0 (118.0–140.0) 122.0 (114.0–134.0) <0.001
DBP (mmHg) 84.5 (76.8–91.3) 82.0 (76.0–90.0) 78.0 (70.0–86.0) <0.001
TG (mg/dL) 125.5 (83.0–174.3) 115.0 (78.0–180.0) 100.0 (73.0–160.0) 0.036
LDL-C (mg/dL) 118.5 (101.8–146.0) 120.0 (101.5–139.5) 118.0 (100.0–137.0) 0.28
HDL-C (mg/dL) 52.0 (43.0–60.3) 51.0 (43.5–61.0) 51.0 (43.0–60.0) 0.34
FBG (mg/dL) 95.0 (90.0–102.3) 94.0 (88.5–103.0) 93.0 (88.0–100.0) 0.07
eGFR (ml/min/1.73 m2) 81.3 (73.7–90.4) 81.8 (73.6–90.6) 80.8 (72.4–89.1) 0.16
hsCRP (mg/L) 0.46 (0.27–0.93) 0.40 (0.21–0.78) 0.33 (0.19–0.58) <0.001
esRAGE (pg/mL) 208.1 (170.3–260.9) 320.4 (278.3–374.6) 480.9 (411.9–573.9) <0.001
Total energy intake (kcal/day) 1882.0 (1553.8–2309.5) 1866.6 (1523.5–2315.3) 1854.6 (1450.2–2196.5) 0.063
PA     
  <1.0 METs · hours/week (%) 20.6 20.7 26.6 0.011
  1.0–22.0 METs · hours/week (%) 38.7 42.6 44.3  
  ≥23.0 METs · hours/week (%) 40.7 36.7 29.1  
Smoking status     
  Never smoker (%) 39.5 38.4 32.1 0.020
  Former smoker (%) 15.5 10.1 10.5  
  Current smoker (%) 45.0 51.5 57.4  
Drinking status     
  Non-drinker (%) 12.2 15.6 21.1 <0.001
  ≤ 3 day(s)/week (%) 29.0 35.4 35.4  
  4–6 days/week (%) 21.8 18.2 18.6  
  Every day (%) 37.0 30.8 24.9  
Sleep time, ≥6 and ≤8 hours/day (%) 80.3 81.0 76.8 0.35
Education (≥college, %) 34.0 32.9 35.4 0.75
Desk work (%) 80.3 79.3 76.4 0.30
Being married (%) 83.6 78.5 79.3 0.24
Depressive symptoms (SDS ≥40, %) 33.6 28.7 32.1 0.72
Number of MetS components (%)     
  No 11.3 20.7 30.4 <0.001
  1 component 31.1 26.2 34.2  
  2 components 26.9 25.7 18.1  
  ≥3 components 30.7 27.4 17.3  
Central obesity (%) 33.6 30.8 15.6 <0.001
Elevated BP (%) 71.0 57.4 44.3 <0.001
Elevated FBG (%) 32.8 32.9 25.3 0.078
Elevated TG (%) 35.3 35.4 27.0 0.054
Reduced HDL-C (%) 14.7 13.5 13.9 0.81
  1. aData are medians (interquartile range) or proportions. sRAGE, soluble receptor of advanced glycation end-products; BMI, body mass index; WC, Waist circumference; SBP, systolic blood pressure; DBP, diastolic blood pressure; TG, triglyceride; LDL-C, low density lipoprotein cholesterol; HDL-C, high density lipoprotein cholesterol; FBG, fasting blood glucose; eGFR, estimated glomerular filtration rate; hsCRP, high sensitivity C-reactive protein; esRAGE, endogenous secretory RAGE; PA, physical activity; SDS, Self-rating Depression Scale; MetS, metabolic syndrome.
  2. bAnalysis of variance or χ2 test.