Variable | Lacunar | P | LAAS | P | CEI | P | |||
---|---|---|---|---|---|---|---|---|---|
Number | With metabolic syndrome (n: 49) | Without metabolic syndrome (n 52) | Â | With metabolic syndrome (n: 45) | Without metabolic syndrome (n: 37) | Â | With metabolic syndrome (n:32) | Without metabolic syndrome (n:35) | Â |
SBP/DBP (mm/Hg) | 148±6.5/94±4.5 | 144±45/9235 | 0.020 | 146±3.4 /93±4.5 | 145.5/91±2.9 | 0.89 | 144±3.8/ 90±3.1 | 143±2.8/90±4.1 | 0.71 |
Diabetes (n/%) | 27 (55.10 ) | 22 (42.30) | 0.025 | 19 (42.22 ) | 17 (45.94) | 0.71 | 9 ( 28.13) | 10 (28.57 ) | 0.51 |
Hypertension (n/%) | 29 (59.18 ) | 28 (53.84) | 0.040 | 19 (41.30 ) | 20 (54.05) | 0.013 | 14 ( 43.75) | 12 (34.28) | 0.011 |
Previous stroke (n/%) | 19 (38.77) | 14 (26.92) | 0.010 | 16 (34.78) | 10 (27.02) | 0.041 | 11 (34.37) | 9 (25.71) | 0.027 |
AIx (%) | 116. 3.5 | 112 ± 2.8 | 0.030 | 111±3.7 | 108±2.9 | 0.031 | 108±4.4 | 107±3.5 | 0.021 |
PWV (m/sec) | 14.45±2.6 | 12.81 ±2.1 | 0.030 | 11.2 ± 2.31 | 10.4 ± 2.22 | 0.030 | 11.48 ± 1.98 | 11.25±2,65 | 0.030 |
NIHSS | 17.65±14.59 | 15.64 ± 8.73 | 0.021 | 22.51±16.06 | 19.00±12.72 | 0.034 | 25.23±8.78 | 22.23±8.78 | 0.023 |
CAD (n/%) | 18 (36.73) | 14 (26.92) | 0.011 | 16 (35.5) | 12 ( 32.43) | 0.71 | 8 (25) | 8 (20) | 0.07 |
Micro-albuminuria (n/%) | 21 (42.85) | 17 (32.76) | 0.02 | 17 (37.77) | 9 (24.37) | 0.03 | 9 ( 28.12) | 7 (20) | 0.045 |
Carotid plaque (n/%) | 14 (28.57) | 9 (17.30 ) | 0.031 | 16 (35.55) | 11 ( 29.79 ) | 0.023 | 7 (21.87) | 5 (14.28 ) | 0.02 |
LVH (n/%) | 11 (22.44) | 14 (26.92) | 0.021 | 9 (20) | 6 (16.27 ) | 0.011 | 10 ( 31.25) | 9 (25.71) | 0.03 |
Previous brain infarct at neuro-imaging | 18 (36.73) | 12 (23.07) | 0.011 | 14 (30.43) | 9 ( 24.32) | 0.021 | 9 (28.12) | 7 (20) | 0.02 |
WMHLS (n/%) | 19 (38.77) | 14 (26.92) | 0.021 | 13 (28.26) | 8 (21.62) | 0.032 | 11 (34.37) | 8 (22.85 ) | 0.021 |
CRP (mg/dl) | 4.1 ± 2,3 | 3.5 ± 2.0 | 0.011 | 5.0 ± 1.8 | 3.9 ± 2.1 | 0.018 | 5.8 ± 1.6 | 4.1 ± 1.5 | 0.020 |
IL-1-beta (pg/ml) | 7 (5-11) | 5.2 (3-8) | 0.012 | 9 (5-12) | 7.9 (4.5-12) | 0.017 | 12 (6-17) | 10.8 (6-14) | 0.021 |
IL-6 (pg/ml) | 9.8 (6,5-19) | 8 (6-21) | 0.021 | 12 (6-27) | 10.4 (5-23.5) | 0.014 | 13.5 (5-31) | 10.2 (4-26) | 0.019 |
TNF-α (pg/ml) | 29.5 (9.5-33) | 23.5 (8. 5-29) | 0.025 | 41.5 (11.25-47) | 37.5 (11.6-41) | 0.031 | 43.5 (21-58) | 35.5 (20-50) | <0.05 |
E-selectin (ng/ml) | 5.05 (1.8-5.7) | 3.25 (1.7-5.7) | <0.05 | 4.85 (1.96-7.9) | 2.75 (1.6-5.6) | <0.05 | 4.15 (2.2-4.1) | 3.55 (2.1-4.1) | 0.011 |
P-selectin (ng/ml) | 4.5 (2-6.8) | 3.1 (2-4.7) | 0.022 | 5.4 (2-8.0) | 4.3 (2.7-6) | 0.034 | 6.2 (3-8.9) | 4.9 (2-7.5) | 0.018 |
VICAM-1 (ng/ml) | 19 (10.1-21) | 15 (8.1-22) | 0.031 | 17.5 (9.2-20) | 15 (8.2-19.8) | 0.022 | 19 (10.1-25) | 17.8 (11.1-23) | 0.041 |
ICAM-1 (ng/ml) | 20.8 (15.2-27 ) | 15.8 (10.2-17 ) | <0.05 | 18.9 (11.2-23) | 16.9 (9.8-20) | 0.028 | 22.6 (12.2-29) | 21.3 (10-27) | 0.021 |
IL-10 (pg/ml) | 2.95 (2-7) | 3.15 (2-8) | 0.45 | 2.96 (2-7) | 3.17 (2-6) | 0.52 | 3.2 (2-9) | 23.2 (2-9) | 0.39 |
vWF (ng/ml) | 12 (4-19) | 9 (4-16) | <0.05 | 14 (5-19) | 11 (5-16) | <0.05 | 14 (6-18) | 12 (6-18) | 0.023 |
PAI-1 (pg/ml) | 145 (97.5-178) | 137 (98.5-149) | <0.05 | 139 (79.4-165) | 128(91.5-135) | <0.05 | 139 (99.0-145) | 109 (99.0-145) | <0.05 |
TPA (pg/ml) | 28 (16.15-39) | 24 (12.15-35) | 0.021 | 26.7 (11.4-31) | 22 (10.5-29) | 0.031 | 24 (12.1-47) | 20 (10.1-39) | 0.021 |