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Table 3 List of SNPs selected in the present study

From: Genetic variation at the CYP2C19 gene associated with metabolic syndrome susceptibility in a South Portuguese population: results from the pilot study of the European Health Examination Survey in Portugal

Mechanisms Gene NCBI ID Alteration Reference Control Obtained HWE
MAF1(N) MAF(N) P-value 2
Glucose/insulin homeostasis CDKAL1 rs7754840 C → G [19] 0.336 (226) 0.286 (206) 0.456
  CDKN2A/B rs10811661 C → T [19] 0.199 (226) 0.201 (206) 0.056
  HHEX rs1111875 A → G [19] 0.416 (226) 0.371 (206) 0.558
  IGF2BP2 rs4402960 G → T [19] 0.280 (118) 0.272 (206) 0.422
  IL6 rs1800795 C → G [19] 0.465 (226) 0.337 (206) 0.917
  KCNJ11 rs5219 C → T [19] - 0.333 (206) 0.532
  KCNQ1 rs2237892 C → T [19] 0.075 (226) 0.051 (206) 1.000
  MTNR1B rs10830963 C → G [20] 0.300 (120) 0.223 (206) 0.264
  PPARG rs1801282 C → G [19] 0.076 (118) 0.093 (205) 1.000
  SLC30A8 rs13266634 C → T [19] 0.239 (226) 0.286 (206) 0.761
  TCF7L2 rs7903146 C → T [19] 0.279 (226) 0.303 (205) 0.256
  ADCY5 rs11708067 A → G [20] 0.226 (226) 0.199 (206) 0.835
  KCNQ1 rs231362 C → T [19] 0.482 (112) 0.234 (128) 0.214
Cardiovascular regulation ACE rs4646994 Ins/Del [21] - 0.420 (206) 0.171
  NOS1AP rs12143842 C → T [22] 0.188 (224) 0.265 (206) 0.827
  ADRB1 rs1801252 A → G [23] - 0.108 (206) 0.711
  ADRB2 rs1042714 C → G [24] 0.467 (120) 0.407 (204) 0.898
  ADRB2 rs1042713 A → G [24] 0.358 (226) 0.362 (206) 0.903
  NOS3 rs1799983 G → T [24] 0.342 (120) 0.417 (206) 0.072
  LDLR rs2228671 C → T [25] 0.106 (226) 0.124 (206) 1.000
  NOS3 rs2070744 C → T [24] - 0.451 (206) 0.892
Body mass Index GNPDA2 rs10938397 A → G [26] 0.446 (112) 0.481 (206) 0.309
  MTCH2 rs10838738 A → G [26] 0.363 (226) 0.282 (206) 0.855
  NPC1 rs1805081 A → G [26] 0.467 (120) 0.288 (206) 0.385
  PTER rs10508503 C → T [26] 0.092 (218) 0.075 (206) 1.000
  SH2B1 rs7498665 A → G [26] 0.382 (226) 0.303 (206) 0.483
  FTO rs9939609 A → T [26] 0.449 (118) 0.361 (205) 0.396
  ADRB3 rs4994 C → T [27] 0.088 (226) 0.090 (205) 1.000
  GABRA2 rs279871 A → G [28] - 0.434 (206) 0.376
  NPY rs16147 A → G [29] 0.491 (226) 0.450 (206) 0.222
  TMEM18 rs6548238 C → T [26] 0.150 (220) 0.127 (205) 0.542
Lipid/Drug metabolism APOE rs7412 C → T [25] - 0.027 (161) 1.000
  CYP2C8 rs10509681 C → T [30] 0.137 (226) 0.129 (206) 0.750
  CYP2C9 rs1799853 C → T [30] 0.104 (106) 0.138 (206) 0.750
  CYP2D6 rs16947 A → G [31] - 0.393 (206) 0.845
  CYP2C19 rs4244285 G → A [32] 0.155 (116) 0.129 (206) 1.000
  TPMT rs1142345 A → G [33] 0.027 (226) 0.032 (205) 1.000
  1. 1Values referring to the HAPMAP-CEU population, available in the NCBI database [18].
  2. 2P-values were obtained by “HardyWeinberg” R package, based on the χ2 -test.