Table 3 Cumulative incidence and rate of hypoglycemia in insulin-naïve group (N = 3732), according to patient characteristics
Characteristics | Total patients, N | Patients having hypoglycemia, n (%) | P value | Number needed to harm (95% CI) | Patient-years | Episodes, n | Incidence rate (episodes/patient-year) | |
|---|---|---|---|---|---|---|---|---|
Age (years) | <65 | 2046 | 14 (0.7) | < 0.05 | Reference | 880.5 | 21 | 0.024 |
≥65 | 1678 | 27 (1.6) | 108 (62–445) | 714.2 | 36 | 0.050 | ||
Diabetic complications | No microvascular complication | 1889 | 18 (1.0) | < 0.05 | Reference | 811.1 | 24 | 0.030 |
Neuropathy only | 297 | 6 (2.0) | 94 (n.s.) | 127.9 | 6 | 0.047 | ||
Retinopathy only | 318 | 1 (0.3) | -* | 138.3 | 1 | 0.007 | ||
Nephropathy only | 356 | 2 (0.6) | -* | 152.5 | 5 | 0.033 | ||
Neuropathy + Retinopathy | 174 | 1 (0.6) | -* | 74.9 | 1 | 0.013 | ||
Neuropathy + Nephropathy | 142 | 0 (0.0) | -* | 59.5 | 0 | 0.000 | ||
Retinopathy + Nephropathy | 154 | 5 (3.2) | 44 (n.s.) | 64.1 | 7 | 0.109 | ||
Neuropathy + Retinopathy + Nephropathy | 301 | 5 (1.7) | 141 (n.s.) | 126.4 | 6 | 0.047 | ||
eGFR (mL/min/1.73 m2) | 90≤ | 933 | 3 (0.3) | < 0.01 | Reference | 400.6 | 4 | 0.010 |
60≤, <90 | 1375 | 12 (0.9) | 181 (n.s.) | 589.0 | 13 | 0.022 | ||
<60 | 532 | 11 (2.1) | 57 (33–207) | 225.0 | 16 | 0.071 | ||
Unknown | 892 | 15 (1.7) | 74 (44–227) | 382.1 | 24 | 0.063 | ||
PPG (mg/dL) | <140 | 45 | 1 (2.2) | < 0.01 | 57 (n.s.) | 19.1 | 1 | 0.052 |
140≤, <180 | 132 | 5 (3.8) | 30 (15–4008) | 57.2 | 8 | 0.140 | ||
180≤, <220 | 235 | 3 (1.3) | 125 (n.s.) | 103.5 | 7 | 0.068 | ||
≥220 | 1043 | 5 (0.5) | Reference | 446.7 | 13 | 0.029 | ||