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Table 2 Alteration in clinical data of subjects grouped based on percentage change in BDNF 1

From: Brain-derived neurotrophic factor, but not body weight, correlated with a reduction in depression scale scores in men with metabolic syndrome: a prospective weight-reduction study

  Minor BDNF change Greater BDNF increase P
(n = 18) (n = 18)
Body weight (kg) -7.7±4.8* -9.1±5.4*  
(%) -8.2%±5.2% -9.2%±5.2% 0.752
Waist circumference (cm) -9.3±5.9* -10.0±5.8*  
(%) -8.5%±5.1% -9.0%±5.3% 0.812
Systolic BP (mmHg) -10±18* -20±22*  
(%) -6.6%±12.9% -13.6%±13.7% 0.129
Diastolic BP (mmHg) -5±8* -10±12*  
(%) -6.4%±9.1% -11.1%±14.1% 0.223
Fasting glucose (mmol/L) -0.2±0.5 -0.4±0.6*  
(%) -2.2%±8.7% -5.9%±10.9% 0.159
HOMA IR -1.0±1.0* -2.3±3.3*  
(%) -24.4%±19.6% -31.9%±32.1% 0.229
Triglyceride (mmol/L) -1.5± 3.2* -0.8±0.9*  
(%) -32.3%±21.5% -30.9%±28.1% 0.752
Total cholesterol (mmol/L) -0.6±0.9* -0.1±0.6*  
(%) -8.3%±13.5% -3.0%±11.2% 0.164
LDL cholesterol (mmol/L) -0.4±0.5* -0.1±0.6  
(%) -8.5%±18.0% -2.1%±18.2% 0.206
HDL cholesterol (mmol/L) 0.1±0.1 0.1±0.3  
(%) 8.8%±15.2% 8.4%±25.0% 0.899
Serum creatinine -4.5±8.2* 1.6±17.7  
(%) -5.2%±9.2% 2.2%±18.0% 0.056
AST (U/L) -7±10* -11±10*  
(%) -17.0%±25.0% -28.1%±24.1% 0.129
ALT (U/L) -12±14* -19±13*  
(%) -25.6%±27.6% -36.8%±19.6% 0.248
CRP (mg/L) -1.7±4.7* -0.7±2.1  
(%) -15.9%±78.1% -1.6%±60.3% 0.343
BDNF (ng/ml) 0.7±1.9 5.7±2.2*  
(%) 3.2%±8.8% 31.3%±12.4% <0.001
Zung SDS 2.3±6.7 -3.9±6.2*  
(%) 8.8%±23.9% -7.8%±13.9% 0.009
  1. *means P value less than 0.05 intra group.
  2. 1 cutoff value: median (16.1%) of the change percentage of BDNF.
  3. ALT = alanine aminotransferase, AST = aspartate aminotransferase, BDNF = brain-derived neurotrophic factor, BP = blood pressure, CRP = C-reactive protein, HDL = high-density lipoprotein, HOMA-IR = homeostasis model assessment of insulin resistance, LDL = low-density lipoprotein, Pc = post-challenge, Zung SDS = Zung Self-Rating Depression Scale.