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Table 1 The baseline data of subjects based on percentage change in BDNF 1

From: Brain-derived neurotrophic factor, but not body weight, correlated with a reduction in depression scale scores in men with metabolic syndrome: a prospective weight-reduction study

  Minor BDNF change Greater BDNF increase P
(n = 18) (n = 18)
Age (year) 41±9 47±11 0.084
Body weight (kg) 95.6±13.8 98.3±11.4 0.319
BMI (kg/m2) 33.5±4.2 33.4±3.6 0.849
Waist circumference (cm) 108.1±10.4 110.0±7.8 0.288
Systolic BP (mmHg) 129±16 141±18 0.059
Diastolic BP (mmHg) 79±12 82±13 0.438
Fasting glucose (mmol/L) 5.5±0.9 5.7±0.7 0.090
Fasting insulin (μIU/ml) 15.6±5.2 22.8±14.0 0.034
HOMA IR 3.9±1.5 5.9±3.7 0.029
Triglyceride (mmol/L) 4.0±7.1 2.5±1.1 0.812
Total cholesterol (mmol/L) 5.5±1.6 5.0±0.7 0.393
LDL cholesterol (mmol/L) 3.3±0.9 3.2±0.6 0.486
HDL cholesterol (mmol/L) 1.0±0.2 1.0±0.2 0.568
Serum creatinine 81.4±12.9 81.2±16.9 0.887
AST (U/L) 28.7±10.4 34.4±11.4 0.081
ALT (U/L) 40±17 48±21 0.241
CRP (mg/L) 3.5±4.8 2.2±2.0 0.558
BDNF (ng/ml) 43.7±7.5 37.2±6.8 0.011
Zung SDS 37.3±7.1 38.0±10.4 0.646
  1. 1cutoff value: median (16.1%) of the change percentage of BDNF.
  2. ALT = alanine aminotransferase, AST = aspartate aminotransferase, BDNF = brain-derived neurotrophic factor, BMI = body mass index, BP = blood pressure, CRP = C-reactive protein, HDL = high-density lipoprotein, HOMA-IR = homeostasis model assessment of insulin resistance, LDL = low-density lipoprotein, Zung SDS = Zung Self-Rating Depression Scale.