Skip to main content

Advertisement

Table 5 Association between cardiovascular risk factor in parents and the presence of metabolic syndrome in their offspring in Framingham Heart Study (N = 1193)

From: Parent-offspring association of metabolic syndrome in the Framingham Heart Study

Risk factors Metabolic syndrome
Female offspring N = 628 Male offspring N = 565
   Odds ratio (95% CI) P value Odds ratio (95% CI) P value
Mother
Elevated BPb Unadjusted 2.04 (1.16-3.58) 0.01 1.77 (1.01-3.11) 0.04
  Adjusteda 1.42 (0.71-2.8) 0.32 1.28 (0.67-2.45) 0.46
Impaired BGc Unadjusted 3.15 (1.61-6.17) 0.001 0.801 (0.37-1.7) 0.57
  Adjusteda 2.03 (1.02- 9.31) 0.04 0.40 (0.18-1.22) 0.12
Obesityd Unadjusted 1.81 (1.19-2.74) 0.005 1.596 (1.02-2.5) 0.04
  Adjusteda 1.58 (0.98-2.56) 0.06 1.41 (0.83-2.39) 0.20
Raised total-Ce Unadjusted 1.15 (0.79-1.67) 0.475 1.49 (1.00-2.22) 0.05
  Adjusteda 1.12 (0.72-1.80) 0.38 1.60 (0.99-2.58) 0.05
Low HDL-Cf Unadjusted 2.05 (1.40-3.00) 0.000 1.39 (0.89-1.95) 0.15
  Adjusteda 2.01 (1.36-3.32) 0.001 1.47 (0.93-2.36) 0.09
Father
Elevated BP Unadjusted 1.21 (0.54-2.74) 0.64 1.37 (0.64-2.90) 0.41
  Adjusteda 0.88 (0.32-1.84) 0.48 1.62 (0.65-4.00) 0.24
Impaired BG Unadjusted 3.35 (1.60-7.02) 0.001 1.36 (0.60-2.66) 0.53
  Adjusteda 4.91 (1.77-11.67) 0.001 1.38 (0.56-3.36) 0.48
Obesity Unadjusted 1.29 (0.73-2.28) 0.39 1.08 (0.61-1.92) 0.79
  Adjusteda 1.81 (0.87-3.6) 0.12 1.31 ( 0.67-2.67) 0.4
Raised total-C Unadjusted 1.33 (0.81-2..21) 0.26 0.93 (0.56-1.54) 0.78
  Adjusteda 1.42 (0.79-2.68) 0.22 0.83 (0.45-1.52) 0.54
Low HDL-C Unadjusted 1.53 (0.84-2.77) 0.16 1.43 (0.81-2.42) 0.22
  Adjusteda 1.48 (0.73-2.98) 0.27 1.45 (0.77-2.74) 0.24
  1. BP: Blood pressure, BG: Blood glucose, Total-C: Total Cholesterol, HDL-C: HDL cholesterol.
  2. aThe multivariate models are adjusted for age, education, smoking, alcohol consumption, physical activity score.
  3. bBlood pressure ≥ 130 mm Hg systolic or ≥ 85 mm Hg diastolic or on drug treatment.
  4. crandom blood glucose level ≥ 11.1 mmol/l or if they used insulin or oral hypoglycemic agents.
  5. dbody mass index ≥ 30.
  6. etotal cholesterol level ≥ 6.20 mmol/l and/or use of cholesterol-lowering medications.
  7. fHDL cholesterol levels (<1.03 mmol/l for men and < 1.3 mmol/l in women or on drug treatment.