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Table 4 Association between parental and offspring’s metabolic syndrome in Framingham Heart Study (N = 1193)

From: Parent-offspring association of metabolic syndrome in the Framingham Heart Study

Metabolic syndrome Metabolic syndrome
Female offspring or daughters (N = 628) Male offspring or sons (N = 565)
   Odds ratio (95% CI) P value Odds ratio (95% CI) P value
Mother Unadjusted 1.96 (1.31-2.93) 0.001 1.26 (0.81-1.94) 0.30
  Adjusteda 1.63 (1.02-2.61) 0.04 1.17 (0.70-1.94) 0.54
Father Unadjusted 1.24 (0.67-2.32) 0.50 0.97 (0.50-1.89) 0.86
  Adjusteda 1.21 (0.59-3.12) 0.19 1.12 (0.53-2.50) 0.72
Both parents Unadjusted 3.96 (1.23-9.77) 0.01 4.88 (1.20-20.71) 0.02
  Adjusteda 3.64 (1.11-13.07) 0.015 4.21 (0.69-25.9) 0.11
  1. Metabolic Syndrome defined as having at least three of the following five components: (1) abdominal obesity or large waist circumference (>102 cm for men and > 88 cm for women); (2) high triglyceride levels (fasting plasma triglyceride concentration ≥ 1.7 mmol/l or on drug treatment); (3) low HDL cholesterol levels (<1.03 mmol/l for men and < 1.3 mmol/l in women or on drug treatment); (4) elevated blood pressure (≥130 mm Hg systolic or ≥ 85 mm Hg diastolic or on drug treatment); or, (5) IFG or impaired fasting glucose (≥6.1 mmol/l or on drug treatment).
  2. aThe multivariate models are adjusted for age, education, smoking, alcohol consumption, physical activity score.