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Table 4 Association between parental and offspring’s metabolic syndrome in Framingham Heart Study (N = 1193)

From: Parent-offspring association of metabolic syndrome in the Framingham Heart Study

Metabolic syndrome

Metabolic syndrome

Female offspring or daughters (N = 628)

Male offspring or sons (N = 565)

  

Odds ratio (95% CI)

P value

Odds ratio (95% CI)

P value

Mother

Unadjusted

1.96 (1.31-2.93)

0.001

1.26 (0.81-1.94)

0.30

 

Adjusteda

1.63 (1.02-2.61)

0.04

1.17 (0.70-1.94)

0.54

Father

Unadjusted

1.24 (0.67-2.32)

0.50

0.97 (0.50-1.89)

0.86

 

Adjusteda

1.21 (0.59-3.12)

0.19

1.12 (0.53-2.50)

0.72

Both parents

Unadjusted

3.96 (1.23-9.77)

0.01

4.88 (1.20-20.71)

0.02

 

Adjusteda

3.64 (1.11-13.07)

0.015

4.21 (0.69-25.9)

0.11

  1. Metabolic Syndrome defined as having at least three of the following five components: (1) abdominal obesity or large waist circumference (>102 cm for men and > 88 cm for women); (2) high triglyceride levels (fasting plasma triglyceride concentration ≥ 1.7 mmol/l or on drug treatment); (3) low HDL cholesterol levels (<1.03 mmol/l for men and < 1.3 mmol/l in women or on drug treatment); (4) elevated blood pressure (≥130 mm Hg systolic or ≥ 85 mm Hg diastolic or on drug treatment); or, (5) IFG or impaired fasting glucose (≥6.1 mmol/l or on drug treatment).
  2. aThe multivariate models are adjusted for age, education, smoking, alcohol consumption, physical activity score.