Skip to main content

Table 3 Adjusted odds ratio (95% confidence interval) for 4-years incidence of type 2 diabetes according to quartile groups of liver enzymes (AST, ALT, and GGT) at baseline in males

From: The association between liver enzymes and risk of type 2 diabetes: the Namwon study

 

Q1

Q2

Q3

Q4

P for trend

AST (units/l)

≤20

21 to 24

25 to 30

≥31

 

Cases/persons at risk

49/620

56/656

64/687

66/640

 

Model 1

1

1.09 (0.73-1.62)

1.20 (0.81-1.77)

1.34 (0.91-1.98)

0.116

Model 2

1

1.11 (0.74-1.66)

1.10 (0.74-1.65)

1.21 (0.80-1.83)

0.390

Model 3

1

1.12 (0.73-1.71)

1.09 (0.72-1.65)

1.15 (0.76-1.76)

0.565

Model 4

1

0.98 (0.63-1.52)

0.93 (0.61-1.43)

1.07 (0.69-1.66)

0.794

ALT (units/l)

≤15

16 to 20

21 to 29

≥30

 

Cases/persons at risk

31/615

46/632

81/710

77/646

 

Model 1

1

1.49 (0.93-2.39)

2.49 (1.62-3.83)

2.67 (1.72-4.15)

<0.001

Model 2

1

1.42 (0.89-2.28)

2.19 (1.41-3.41)

2.11 (1.33-3.35)

<0.001

Model 3

1

1.53 (0.93-2.52)

2.24 (1.40-3.59)

2.31 (1.42-3.75)

<0.001

Model 4

1

1.36 (0.82-2.27)

2.03 (1.26-3.29)

1.95 (1.18-3.21)

0.004

GGT (units/l)

≤19

20 to 30

31 to 54

≥55

 

Cases/persons at risk

38/661

44/651

72/635

81/656

 

Model 1

1

1.20 (0.77-1.89)

2.14 (1.42-3.23)

2.38 (1.59-3.57)

<0.001

Model 2

1

1.09 (0.69-1.73)

2.00 (1.28-3.12)

2.13 (1.33-3.41)

<0.001

Model 3

1

1.00 (0.62-1.63)

1.86 (1.17-2.96)

1.97 (1.21-3.22)

0.001

Model 4

1

0.86 (0.52-1.42)

1.57 (0.97-2.54)

1.58 (0.95-2.63)

0.011

  1. Model 1: adjusted for age.
  2. Model 2: Model 1 plus body mass index, waist circumference, total cholesterol, HDL-cholesterol, log-triglyceride, alcohol intake status, smoking status, physical activity, and follow-up period.
  3. Model 3: Model 2 plus log-CRP.
  4. Model 4: Model 3 plus fasting glucose and HOMA.