Table 4 Clinical and laboratory characteristics of type 1 diabetic patients compared by ISS quartiles
From: Insulin resistance and associated factors in patients with Type 1 Diabetes
Variables | ISS 1stquartile | ISS 2ndand 3rdquartiles | ISS4thquartile | P value |
|---|---|---|---|---|
Patients | n = 34 (25.2%) | n = 68 (50.4%) | n = 33 (24.4%) | |
Gender (Male) | 18 (52.9%) | 30 (44.1%) | 10 (30.3%) | 0.063 |
Age (years) | 32 (15–68) | 27 (12–62) | 25 (15–55) | 0.016 |
Duration of diabetes (years) | 17 (1–49) | 16 (2–43) | 10 (0–27) | 0.020 |
BMI (kg/m2)† | 27.5 (19–46) | 24 (17–30) | 21 (18–26) | < 0.001 |
Waist/height ratio (cm) | 56.8 (40.5-78.8) | 49.0 (38.7-61.9) | 43.7 (36.1-51.7) | < 0.001 |
Total insulin dose IU/Lean Mass (kg)§ | 1.43 (0.53-3.35) | 1.05 (0.46-1.77) | 0.92 (0.19-1.63) | 0.002 |
Total lean mass (kg)§ | 0.63 (0.5-0.9) | 0.74 (0.5-1.0) | 0.79 (0.7-0.9) | 0.001 |
Thoracoabdominal fat (kg)§ | 13.13 (7.2-28.7) | 6.28 (1.0-13.6) | 3.4 (1.5-6.9) | < 0.001 |
Leg fat (kg)§ | 7.10 (3.6-12.9) | 5.45 (0.9-16.3) | 4.76 (1.8-10.4) | 0.011 |
Arm fat (kg)§ | 2.65 (1.2-6.8) | 1.36 (0.2-4.9) | 0.816 (0.2-2.2) | 0.001 |
Total lean mass percentage§ | 0.63 (0.5-0.9) | 0.74 (0.5-1.0) | 0.79 (0.7-0.9) | 0.001 |
Total fat percentage§ | 0.37 (0.18-0.50) | 0.25 (0.05-0.49) | 0.20 (0.08-0.34) | < 0.001 |
Thoracoabdominal fat percentage§ | 0.33 (0.22-0.50) | 0.21 (0.05-0.41) | 0.16 (0.06-0.68) | < 0.001 |
Leg fat percentage§ | 0.35 (0.14-0.48) | 0.33 (0.06-0.60) | 0.29 (0.11-0.49) | 0.237 |
Arm fat percentage§ | 0.39 (0.16-0.59) | 0.28 (0.04-0.56) | 0.18 (0.04-0.41) | 0.001 |
Triceps skinfold (mm) | 21.7 (9.7-26.6) | 15.7 (4.3-30.0) | 15.0 (5.3-25.7) | 0.003 |
Scapular skinfold (mm) | 24.3 (14.7-41.7) | 16.0 (6.3-36.0) | 12.0 (6.3-23.7) | < 0.001 |
Acanthosis (yes)* | 6 (19.4%) | 3 (4.6%) | 1 (3.1%) | 0.013 |
Physical activity (yes) | 19 (57.6%) | 43 (63.2%) | 22 (66.7%) | 0.447 |
Family history of DM2 (yes) | 25 (78.1%) | 44 (66.7%) | 24 (75%) | 0.783 |
Total insulin dose (IU/day) | 60 (34–340) | 46 (17–111) | 36 (8–85) | < 0.001 |
Total cholesterol (mg/dL) | 169 (117–282) | 167 (76–332) | 162 (76–250) | 0.268 |
HDL (mg/dL) | 46 (27–87) | 57 (35–107) | 56 (32–124) | 0.004 |
LDL (mg/dL) | 99 (49–178) | 96 (20–252) | 88 (35–150) | 0.127 |