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Table 4 Results of melatonin versus placebo on clinic blood pressure, stratified by African-American or white race

From: Melatonin supplementation to treat the metabolic syndrome: a randomized controlled trial

Parameter Melatonin Placebo P value (mixed model)
SBP average clinic value, mmHg (mean, SD) (n = 39, 38) (n = 38, 37)  
  Whites (n = 22)    
  Pre 123.2 ± 12.7 121.4 ± 11.4  
  Post 119.4 ± 10.9 122.9 ± 12.4  
  Change with treatment (post minus pre) -2.6 ± 11.0 1.7 ± 12.0 0.196
  African-Americans (n = 13)    
  Pre 131.0 ± 21.0 119.1 ± 22.1  
  Post 127.1 ± 18.4 131.6 ± 18.0  
  Change with treatment (post minus pre) -3.9 ± 10.9 12.5 ± 13.7 0.003
DBP average clinic value, mmHg (mean, SD) (n = 39, 38) (n = 38, 37)  
  Whites (n = 22)    
  Pre 73.3 ± 8.4 73.1 ± 5.9  
  Post 71.1 ± 5.6 72.9 ± 6.3  
  Change with treatment (post minus pre) -1.3 ± 7.2 0.0 ± 5.0 0.840
  African-Americans (n = 13)    
  Pre 80.7 ± 14.2 76.2 ± 13.7  
  Post 79.3 ± 14.4 81.1 ± 13.3  
  Change with treatment (post minus pre) -1.4 ± 6.6 4.9 ± 8.6 0.034
  1. DBP = diastolic blood pressure; SBP = systolic blood pressure; SD = standard deviation.