Table 2 Main results comparing the effect of melatonin with placebo on the components of the metabolic syndrome*
From: Melatonin supplementation to treat the metabolic syndrome: a randomized controlled trial
Parameter | Melatonin | Placebo | P value (mixed model) |
|---|---|---|---|
Weight, kg (mean, SD) | |||
Sample size (pre, post) | (n = 39, 38) | (n = 38, 37) | |
Pre | 97.6 ± 16.9 | 96.2 ± 15.7 | |
Post | 95.8 ± 15.9 | 96.8 ± 15.7 | |
Change with treatment (post minus pre) | -1.4 ± 4.4 | -0.02 ± 1.8 | 0.087 |
BMI (mean, SD) | |||
Sample size (pre, post) | (n = 39, 38) | (n = 38, 37) | |
Pre | 34.6 ± 6.7 | 33.8 ± 6.0 | |
Post | 33.7 ± 6.1 | 34.0 ± 6.0 | |
Change with treatment (post minus pre) | -0.4 ± 1.4 | -0.0 ± 0.7 | 0.090 |
Waist circumference, cm (mean, SD) | |||
Sample size (pre, post) | (n = 37, 37) | (n = 38, 37) | |
Pre | 108.8 ± 12.2 | 106.8 ± 10.5 | |
Post | 108.1 ± 11.3 | 108.0 ± 10.6 | |
Change with treatment (post minus pre) (n = 35 Melatonin) | -0.9 ± 5.9 | 1.0 ± 5.5 | 0.155 |
Triglycerides, mg/dL (mean, SD) | |||
Sample size (pre, post) | (n = 39, 38) | (n = 38, 37) | |
Pre | 207.2 ± 271.9 | 175.3 ± 172.1 | |
Post | 142.6 ± 74.1 | 172.4 ± 216.9 | |
Change with treatment (post minus pre) | -66.3 ± 211.8 | -4.2 ± 99.6 | 0.166 |
LDL cholesterol, mg/dL (mean, SD) | |||
Sample size (pre, post) | (n = 39, 38) | (n = 38, 37) | |
Pre | 112.6 ± 32.3 | 112.7 ± 31.2 | |
Post | 108.5 ± 33.2 | 114.6 ± 35.3 | |
Change with treatment (post minus pre) | -3.7 ± 25.6 | 0.1 ± 25.5 | 0.564 |
HDL cholesterol, mg/dL (mean, SD) | |||
Sample size (pre, post) | (n = 39, 38) | (n = 38, 37) | |
Pre | 40.8 ± 7.6 | 42.5 ± 10.1 | |
Post | 40.9 ± 8.3 | 41.5 ± 8.3 | |
Change with treatment (post minus pre) | -0.2 ± 5.8 | -1.1 ± 8.2 | 0.592 |
Fasting glucose, mg/dL (mean, SD) | |||
Sample size (pre, post) | (n = 39, 37) | (n = 38, 37) | |
Pre | 103.4 ± 16.5 | 104.6 ± 13.7 | |
Post | 102.9 ± 17.1 | 101.9 ± 10.2 | |
Change with treatment (post minus pre) | 0.3 ± 13.6 | -3.1 ± 11.0 | 0.287 |
SBP average clinic value, mmHg (mean, SD) | |||
Sample size (pre, post) | (n = 39, 38) | (n = 38, 37) | |
Pre | 126.8 ± 16.3 | 122.3 ± 17.3 | |
Post | 123.4 ± 15.2 | 127.0 ± 15.1 | |
Change with treatment (post minus pre) | -2.7 ± 11.3 | 4.7 ± 13.8 | 0.013 |
DBP average clinic value, mmHg (mean, SD) | |||
Sample size (pre, post) | (n = 39, 38) | (n = 38, 37) | |
Pre | 76.6 ± 11.3 | 75.3 ± 10.3 | |
Post | 75.0 ± 10.8 | 76.4 ± 10.0 | |
Change with treatment (post minus pre) | -1.1 ± 6.9 | 1.1 ± 7.4 | 0.243 |
Ambulatory BP readings | |||
Full 24-hour period | |||
Average SBP, mmHg (mean, SD) | |||
Sample size (pre, post) | (n = 37, 38) | (n = 38, 37) | |
Pre | 131.6 ± 11.6 | 130.4 ± 9.5 | |
Post | 129.6 ± 12.0 | 130.9 ± 12.0 | |
Change with treatment (post minus pre) (n = 36 Melatonin) | -1.4 ± 8.1 | 0.3 ± 8.5 | 0.475 |
Average DBP, mmHg (mean, SD) | |||
Sample size (pre, post) | (n = 37, 38) | (n = 38, 37) | |
Pre | 76.9 ± 9.0 | 76.3 ± 8.2 | |
Post | 75.7 ± 8.6 | 76.8 ± 8.3 | |
Change with treatment (post minus pre) (n = 36 Melatonin) | -1.0 ± 6.3 | 0.4 ± 5.7 | 0.409 |
Wake period (0800 to 2200) | |||
Average SBP, mmHg (mean, SD) | |||
Sample size (pre, post) | (n = 37, 38) | (n = 38, 37) | |
Pre | 136.1 ± 12.4 | 134.2 ± 9.3 | |
Post | 133.2 ± 12.2 | 135.8 ± 12.6 | |
Change with treatment (post minus pre) (n = 36 Melatonin) | -2.2 ± 9.1 | 1.4 ± 10.5 | 0.169 |
Average DBP, mmHg (mean, SD) | |||
Sample size (pre, post) | (n = 37, 38) | (n = 38, 37) | |
Pre | 81.0 ± 9.6 | 79.8 ± 8.0 | |
Post | 78.9 ± 9.1 | 81.6 ± 8.7 | |
Change with treatment (post minus pre) (n = 36 Melatonin) | -1.8 ± 7.3 | 1.8 ± 6.6 | 0.044 |
Sleep period (2200 to 0800) | |||
Average SBP, mmHg (mean, SD) | |||
Sample size (pre, post) | (n = 37, 36) | (n = 38, 37) | |
Pre | 125.8 ± 12.3 | 125.1 ± 11.5 | |
Post | 124.9 ± 13.4 | 123.9 ± 13.5 | |
Change with treatment (post minus pre) (n = 34 Melatonin) | -1.1 ± 9.0 | -1.4 ± 8.9 | 0.807 |
Average DBP, mmHg (mean, SD) | |||
Sample size (pre, post) | (n = 37, 36) | (n = 38, 37) | |
Pre | 71.7 ± 9.1 | 71.2 ± 9.5 | |
Post | 70.7 ± 8.8 | 69.9 ± 8.7 | |
Change with treatment (post minus pre) (n = 34 Melatonin) | -0.7 ± 6.5 | -1.3 ± 6.7 | 0.729 |