Skip to main content

Table 3 Univariate correlation analysis of *percentage changes of fasting HOMA-IR and OGTT-derived insulin-sensitivity index (Matsuda) with *percentage changes of obesity-associated inflammatory markers, adipokines and MRI measured fat index (study subjects: 27 obese non-diabetic men with metabolic syndrome, with weight loss >5%)

From: Correlation between reduction of superior interventricular groove epicardial fat thickness and improvement of insulin resistance after weight loss in obese men

Factors (*percentage changes) HOMA-IR ISI-Matsuda
Correlation coefficients (r) p Correlation coefficients (r) p
BMI 0.201 0.314 −0.485 0.010
MR measured fat index     
  waist −0.014 0.944 −0.434 0.024
  Subcutaneous fat area 0.216 0.280 −0.642 <0.001
  Abdominal visceral fat area 0.094 0.641 −0.369 0.058
  Epicardial adipose tissue thickness     
  Basal short axis plane     
   SIVG 0.408 0.035 −0.501 0.008
   IIVG 0.259 0.193 −0.359 0.066
   RVFW 0.342 0.080 −0.201 0.314
Horizontal long axis plane     
   RAVG −0.049 0.808 −0.213 0.287
   LAVG −0.064 0.753 −0191 0.340
   AIVG 0.018 0.929 −0.198 0.321
HDL-C −0.001 0.995 0.195 0.329
Triglyceride 0.037 0.856 −0.234 0.240
MCP-1 −0.164 0.414 0.050 0.803
HsCRP −0.003 0.989 −0.022 0.911
Adipokines     
Adiponectin 0.093 0.643 0.269 0.175
Leptin 0.685 <0.001 −0.439 0.022
PAI −0.028 0.888 −0.176 0.379
  1. AIVG: anterior interventricular groove; BMI (kg/m2): body mass index = body weight (kg)/height2 (m); HDL-C: high-density lipoprotein cholesterol; HOMA-IR: homeostasis model assessment of insulin resistance, defined as glucose mg/dl × insulin μU/mL/405; Hs-CRP: high sensitivity C-reactive protein; IIVG: inferior interventricular groove; LAVG: left atrioventricular groove; MCP-1: monocyte chemotactic protein-1; Oral glucose tolerance test (OGTT)-derived insulin-sensitivity index (ISI), Matsuda: 10,000/sqrt (FBG × FPI × G × I), where FPG is fasting glucose (mM), FPI is fasting insulin (μIU/ml), G is mean glucose (mM), I is mean insulin (μIU/ml) during the OGTT; PAI-1: plasminogen activator protein-1; RAVG: right atrioventricular groove; RVFW: right ventricular free wall; SIVG: superior interventricular groove.
  2. *Percentage of changes = (after - before)/before weight loss.