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Table 1 Changes of anthropometric, serum or plasma biochemical data and adipokines in obese non-diabetic men with metabolic syndrome with weight loss >5% (N = 27) by diet and exercise program

From: Correlation between reduction of superior interventricular groove epicardial fat thickness and improvement of insulin resistance after weight loss in obese men

  Before (N = 27) After (N = 27) *Percentage of changes P value
Body weight (kg) 97 ± 14 87 ± 14 −10.7% <0.001
BMI (kg/m2) 33.5 ± 4.1 29.9 ± 4.2 −10.6% <0.001
Fasting glucose (mg/dl) 103 ± 15 97 ± 10 −5.7% 0.002
Fasting insulin (μIU/ml) 18.6 ± 12.1 13.0 ± 7.3 −25.8% 0.005
HOMA-IR (mg/dl × μIU/ml) 4.8 ± 3.2 3.1 ± 1.7 −29.5% 0.003
OGTT glucose AUC (mg/dl × h) 367 ± 79 324 ± 55 −9.8% <0.001
OGTT insulin AUC (μIU/ml × h) 200 ± 99 148 ± 75 −21.1% 0.002
OGTT derived insulin-sensitivity index, Matsuda (mM × μIU/ml)−1 40.6 ± 16.6 64.6 ± 31.2 69.7% <0.001
Total cholesterol (mg/dl) 204 ± 51 187 ± 35 −7.2% 0.011
HDL-C (mg/dl) 40 ± 9 44 ± 10 11.2% 0.021
Triglyceride (mg/dl) 295 ± 515 174 ± 294 −36.6% 0.012
MCP-1 (pg/ml) 277 ± 88 215 ± 66 −19.5% <0.001
Hs-CRP (mg/dL) 0.29 ± 0.41 0.14 ± 0.11 −19.3% 0.061
Adipokines     
Adiponectin (ng/ml) 3197 ± 1803 3377 ± 2140 35.5% 0.431
Leptin (pg/ml) 16034 ± 9932 11673 ± 11362 −21.2% 0.067
PAI-1 (ng/ml) 18.4 ± 8.2 9.7 ± 4.9 −37.0% <0.001
  1. BMI (kg/m2): body mass index = body weight (kg)/height2 (m).
  2. HDL-C: high-density-lipoprotein cholesterol.
  3. HOMA-IR: homeostasis model assessment (HOMA) index of insulin resistance = (fasting glucose mg/dl × fasting insulin μU/mL)/405.
  4. MCP-1: monocyte chemotactic protein-1.
  5. MetS: metabolic syndrome.
  6. OGTT glucose AUC: oral glucose tolerance test, area under the curve for glucose.
  7. OGTT insulin AUC: oral glucose tolerance test, area under the curve for insulin.
  8. OGTT insulin-sensitivity index (Matsuda): 10,000⁄sqrt (FBG × FPI × G × I) where FPG is fasting glucose (mM), FPI is fasting insulin (μIU/ml), G is mean glucose (mM), I is mean insulin (μIU/ml) during the OGTT.
  9. PAI-1: plasminogen activator inhibitor-1.
  10. *Percentage of changes = (after - before)/before weight loss, mean value.