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Table 2 Results of the MTTs performed before and after 12 weeks of treatment with bezafibrate

From: Bezafibrate improves insulin resistance evaluated using the glucose clamp technique in patients with type 2 diabetes mellitus: a small-scale clinical study

  Baseline 12 weeks p
HbA1c (NGSP) (%) 7.30 ± 0.55 7.02 ± 0.52 <0.05
HbA1c (NGSP) (mmol/mol) 54.5 ± 5.6 51.6 ± 5.3 <0.05
FPG (mmol/L) 7.95 ± 1.15 6.98 ± 1.07 <0.01
HOMA-IR 2.66 ± 1.42 2.20 ± 0.94 0.08
HOMA-β 38.97 ± 34.28 46.44 ± 28.59 0.12
Matsuda index 5.59 ± 2.04 5.98 ± 2.48 0.47
Insulinogenic index 0.92 ± 0.81 0.67 ± 0.69 0.18
IRI (pmol/L) Fasting 54.7 ± 29.4 51.8 ± 23.5 0.51
  120 min* 257.1 ± 153.0 292.2 ± 176.1 0.18
CPR (nmol/L) Fasting 0.55 ± 0.25 0.50 ± 0.14 0.28
  120 min* 1.54 ± 0.52 1.56 ± 0.42 0.82
TG (mmol/L) Fasting 1.84 ± 0.88 1.14 ± 0.41 <0.01
  120 min* 2.13 ± 0.97 1.47 ± 0.40 <0.01
RLP-C (mmol/L) Fasting 0.25 ± 0.16 0.12 ± 0.05 <0.05
  120 min* 0.26 ± 0.16 0.14 ± 0.06 <0.05
TC (mmol/L) 5.83 ± 1.03 5.30 ± 0.60 <0.05
LDL-C (mmol/L) 3.56 ± 0.83 2.92 ± 0.55 <0.05
HDL-C (mmol/L) 1.50 ± 0.24 1.66 ± 0.29 <0.05
hs-CRP (mg/dl) 0.11 ± 0.10 0.09 ± 0.12 0.38
Adiponectin (μg/mL) 7.81 ± 2.52 8.37 ± 3.90 0.31
AST (IU/L) 32.3 ± 21.7 28.9 ± 19.7 0.05
ALT (IU/L) 39.8 ± 25.8 28.8 ± 19.6 <0.01
γ-GTP (IU/L) 66.5 ± 56.2 30.7 ± 18.2 <0.05
BMI (kg/m2) 26.5 ± 3.1 26.2 ± 2.9 0.14
Waist circumference (cm) 91.8 ± 7.6 93.5 ± 9.2 0.14
  1. Data are mean ± standard deviation.
  2. TC, LDL-C, HDL-C, RLP-C, hs-CRP, adiponectin, AST, ALT, and γ-GTP were measured using fasting blood samples.
  3. *Measured at 120 min after the test meal.
  4. HbA1c = hemoglobin A1c; NGSP = National Glycohemoglobin Standarization Program; FPG = fasting plasma glucose; HOMA-IR = homeostatic model assessment of insulin resistance; HOMA-β = homeostasis model assessment of β cell function; IRI = immunoreactive insulin; CPR = C-peptide immunoreactivity; TG = triglycerides; RLP-C = remnant-like particle cholesterol; LDL-C = low-density lipoprotein cholesterol; HDL-C = high-density lipoprotein cholesterol; hs-CRP = high-sensitivity C-reactive protein; AST = aspartate aminotransferase; ALT = alanine aminotransferase; γ-GTP = γ-glutamyltranspeptidase; BMI = body mass index.