Table 2 Results of the MTTs performed before and after 12 weeks of treatment with bezafibrate

HbA1c (NGSP) (%)

7.30 ± 0.55

7.02 ± 0.52

<0.05

HbA1c (NGSP) (mmol/mol)

54.5 ± 5.6

51.6 ± 5.3

<0.05

FPG (mmol/L)

7.95 ± 1.15

6.98 ± 1.07

<0.01

HOMA-IR

2.66 ± 1.42

2.20 ± 0.94

0.08

HOMA-β

38.97 ± 34.28

46.44 ± 28.59

0.12

Matsuda index

5.59 ± 2.04

5.98 ± 2.48

0.47

Insulinogenic index

0.92 ± 0.81

0.67 ± 0.69

0.18

IRI (pmol/L)

Fasting

54.7 ± 29.4

51.8 ± 23.5

0.51

120 min*

257.1 ± 153.0

292.2 ± 176.1

0.18

CPR (nmol/L)

Fasting

0.55 ± 0.25

0.50 ± 0.14

0.28

120 min*

1.54 ± 0.52

1.56 ± 0.42

0.82

TG (mmol/L)

Fasting

1.84 ± 0.88

1.14 ± 0.41

<0.01

120 min*

2.13 ± 0.97

1.47 ± 0.40

<0.01

RLP-C (mmol/L)

Fasting

0.25 ± 0.16

0.12 ± 0.05

<0.05

120 min*

0.26 ± 0.16

0.14 ± 0.06

<0.05

TC (mmol/L)

5.83 ± 1.03

5.30 ± 0.60

<0.05

LDL-C (mmol/L)

3.56 ± 0.83

2.92 ± 0.55

<0.05

HDL-C (mmol/L)

1.50 ± 0.24

1.66 ± 0.29

<0.05

hs-CRP (mg/dl)

0.11 ± 0.10

0.09 ± 0.12

0.38

Adiponectin (μg/mL)

7.81 ± 2.52

8.37 ± 3.90

0.31

AST (IU/L)

32.3 ± 21.7

28.9 ± 19.7

0.05

ALT (IU/L)

39.8 ± 25.8

28.8 ± 19.6

<0.01

γ-GTP (IU/L)

66.5 ± 56.2

30.7 ± 18.2

<0.05

BMI (kg/m²)

26.5 ± 3.1

26.2 ± 2.9

0.14

Waist circumference (cm)

91.8 ± 7.6

93.5 ± 9.2

0.14