Pioglitazone regulated activities of caspases. A. The activity of the effector caspase3/7 was shown in the control, GW9662, Pioglitazone, PIO + siRNA-PPARγ and PIO + wt-PPARγ treated VSMCs, respectively. B. The activity of the initial caspase of intrinsic pathway-caspase8 in different gr006Fups. C. The activity of the initial caspase of extrinsic pathway-caspase9 in different groups. **P < 0.001, ***P < 0.0001. The activity of different caspases is normalized to the control (100%). Percentage is presented as the mean ± SEM of triplicates. Each experiment has been repeated three times.