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Table 2 Follow-up of plasma creatinine concentrations and urinary albumin excretions

From: Caloric restriction or telmisartan control dyslipidemia and nephropathy in obese diabetic Zücker rats

Animal Serum creatinine (mg/dL)   Albuminuria (mg/day)  
  10 19 Creatinine increase 10 19 Albuminuria increase
Z 0.25 ± 0.05 0.34 ± 0.11 0.05 ± 0.05 4.42 ± 0.86 37.20 ± 17.20 32.78 ± 17.52
ZDFV 0.45 ± 0.38 0.32 ± 0.10 -0.13 ± 0.33 57.31 ± 48.8 323.63 ± 134.3 260.37 ± 124.8*
ZDFT 0.40 ± 0.31 0.28 ± 0.12 -0.16 ± 0.21 24.73 ± 9.6 97.80 ±57.4 73.07 ± 54.2
ZDFD 0.20 ± 0 0.23 ± 0.05 0.03 ± 0.05 19.51 ± 7.81 130.32 ± 66.5 107.62 ± 64.5
  1. Differences between the experimental time-points (weeks 10 and 19) in the non-diabetic and diabetic obese rats. Data are shown as mean ± SD. Significant differences *p < 0.05 vs Zücker, p < 0.05 vs ZDFV. The urinary excretion of albumin in the vehicle group at the completion of the study period was significantly greater than in the other groups, either in the non-diabetic (Z) or in the fatty-diabetic animals with low-calorie diet (ZDFD) and telmisartan (ZDFT). Renal function and plasma creatinine values did not experience any significant change.