Animal | Serum creatinine (mg/dL) | | Albuminuria (mg/day) | |
---|
| 10 | 19 | Creatinine increase | 10 | 19 | Albuminuria increase |
---|
Z | 0.25 ± 0.05 | 0.34 ± 0.11 | 0.05 ± 0.05 | 4.42 ± 0.86 | 37.20 ± 17.20 | 32.78 ± 17.52 |
ZDFV | 0.45 ± 0.38 | 0.32 ± 0.10 | -0.13 ± 0.33 | 57.31 ± 48.8 | 323.63 ± 134.3 | 260.37 ± 124.8* |
ZDFT | 0.40 ± 0.31 | 0.28 ± 0.12 | -0.16 ± 0.21 | 24.73 ± 9.6 | 97.80 ±57.4¶ | 73.07 ± 54.2¶ |
ZDFD | 0.20 ± 0 | 0.23 ± 0.05 | 0.03 ± 0.05 | 19.51 ± 7.81 | 130.32 ± 66.5*¶ | 107.62 ± 64.5*¶ |
- Differences between the experimental time-points (weeks 10 and 19) in the non-diabetic and diabetic obese rats. Data are shown as mean ± SD. Significant differences *p < 0.05 vs Zücker, ¶p < 0.05 vs ZDFV. The urinary excretion of albumin in the vehicle group at the completion of the study period was significantly greater than in the other groups, either in the non-diabetic (Z) or in the fatty-diabetic animals with low-calorie diet (ZDFD) and telmisartan (ZDFT). Renal function and plasma creatinine values did not experience any significant change.