| Body weight (g) | | Glucose (mg/dL) | |
---|
Animal | 10 | 19 | Weight increase | 10 | 19 | Glucose increase |
---|
Z | 330 ± 23 | 517 ± 34 | 187 ± 35 | 150 ± 16 | 188 ± 78 | 38 ± 72 |
ZDFV | 356 ± 22 | 433 ± 35* | 76 ± 22* | 201 ± 96 | 593 ± 63* | 416 ± 103* |
ZDFT | 360 ± 14 | 480 ± 68 | 119 ± 62 | 223 ± 130 | 478 ± 115*¶ | 218 ± 121*¶ |
ZDFD | 337 ± 13 | 495 ± 15¶ | 158 ± 14 | 146 ± 23 | 360 ± 119*¶ | 213 ± 130*¶ |
- Differences between the experimental time-points (weeks 10 and 19) in the non-diabetic and diabetic obese rats. Data are shown as mean ± SD. Significant differences *p < 0.05 vs Zücker, ¶p < 0.05 vs ZDFV. The greater weight increase was seen in the non-diabetic rats (Z) and the fatty-diabetic animals subjected to caloric restriction (ZDFD). Conversely, in the vehicle group (ZDFV), we saw a trend to a slower weight gain but the most marked increase in hyperglycaemia over time.