Differences between the experimental time-points (weeks 10 and 19) in the non-diabetic and diabetic obese rats. Data are shown as mean ± SD. Significant differences *p < 0.05 vs Zücker, ¶p < 0.05 vs ZDFV. The greater weight increase was seen in the non-diabetic rats (Z) and the fatty-diabetic animals subjected to caloric restriction (ZDFD). Conversely, in the vehicle group (ZDFV), we saw a trend to a slower weight gain but the most marked increase in hyperglycaemia over time.