Increased SGLT1 expression in salivary gland ductal cells correlates with hyposalivation in diabetic and hypertensive rats

Table 1 Morphological and functional characteristics of salivary glands of Wistar Kyoto (WKY) rats, diabetic WKY (WKY-D), spontaneously hypertensive rats (SHR) and diabetic SHR (SHR-D)

	WKY	WKY-D	SHR	SHR-D
Parotid weight (mg)	156 ± 5.6	101 ± 6.1***	138 ± 4.6#	124 ± 4.2##
Submandibular weight (mg)	288 ± 7.8	245 ± 13.8*	286 ± 7.2	234 ± 8.4**
Absolute salivary secretion (μL/7 min)	14.4 ± 0.6	6.7 ± 0.40***	8.0 ± 0.81###	3.5 ± 0.18***###
Relative salivary secretion (μl/g tissue/min)	4.6 ± 0.05	2.7 ± 0.06***	2.7 ± 0.07###	1.4 ± 0.02***###
Basal salivary glucose (mg/dL)	6.5 ± 0.32	23.4 ± 1.7***	3.2 ± 0.30#	16.4 ± 1.3***###

Relative salivary secretion was calculated taking into account the sum of parotid and submandibular weights. Data are means ± S.E.M of 5 animals. *P < 0.05, **P < 0.01 and ***P < 0.001 vs respective non-diabetic group; #P < 0.05, ##P < 0.01, ###P < 0.001 vs respective normotensive (WKY) group; One-Way ANOVA, Student-Newman-Keuls post-test.

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