Table 3 Reduced incidence and cancer-related mortality in metformin treated patients
From: Metformin: an old but still the best treatment for type 2 diabetes
Author | Study type | Tumor type | Region | Total participants | Follow up (years) | Confounding adjustment * |
|---|---|---|---|---|---|---|
Evans [135] | Pilot Observational Study | Not specified | Tayside, Scotland. UK | 11,876 | 8 | IMC, smoking, blood pressure, material deprivation |
Bodmer [136] | Retrospective Case control | Breast | UK | 22,661 | 10 | Age, BMI, smoking, estrogen use, diabetes history, HbA1c, renal failure, congestive heart failure, ischemic heart disease |
Li [137] | Prospective case–control | Pancreatic | USA | 1,836 | 4 | Sex, age, smoking, DM-2, duration of diabetes, HbA1c, insulin use, oral antidiabetic medication, IMC, risk factors |
Donadon [138] | Retrospective Case–control | Hepatocellular carcinoma | Italy | 1,573 | 12 | Sex, age, BMI, alcohol abuse, HBV and HCV infection, DM-2, ALT level |
Libby [139] | Retrospective cohort study | Colorectal | Scotland. UK | 8,000 | 9 | Sex, age, BMI, HbA1c, deprivation |
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