Metformin: an old but still the best treatment for type 2 diabetes

Table 1 Effectiveness of metformin in diabetes prevention of patients with impaired glucose tolerance

Study	Randomized	Country	N	Duration years	Mean change in risk MET (%)	Mean change in risk LSM (%)
DPP [7]	yes	USA	3234	3	−31%	−58%
IDPP [9]	yes	India	522	3	−26.4%	−28.2%
Yang et al.[10]	yes	China	321	2.5	−77%	-
DPPOS [11]	yes	USA	2766	5.7	−18%	−34%

DPP: Diabetes Prevention Program, DPP: Indian Diabetes Prevention Program, DPPOS: Diabetes Prevention Outcome Study, MET: Metformin, LSM: Lifestyle modification.

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