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Table 4 Results of logistic regression models of demographic and study treatment parameters associated with weight loss ≥ 1 kg by final visit

From: Initiation of once daily insulin detemir is not associated with weight gain in patients with type 2 diabetes mellitus: results from an observational study

Parameter

Category

Odds ratio

95% confidence interval

p value

Lower

Upper

Basic Model

Baseline HbA1c (%)

 

0.927

0.905

0.950

<0.0001

Age (years)

≥75

0.902

0.776

1.049

0.6660

 

≥70 to < 75

0.969

0.834

1.126

 
 

≥65 to < 70

0.959

0.829

1.109

 
 

≥60 to < 65

1.015

0.885

1.165

 
 

≥55 to < 60

1.020

0.889

1.171

 
 

≥50 to < 55

0.945

0.813

1.098

 
 

< 50 (reference group)

0

.

.

 

Gender

Female vs. Male

0.916

0.849

0.989

0.0229

Duration of Diabetes (years)

>13

0.945

0.844

1.059

0.1681

 

>8.5 to ≤13

0.884

0.795

0.983

 
 

>5 to ≤8.5

0.898

0.807

1.000

 
 

≤5 (reference group)

0

.

.

 

BMI (kg/m2)

≥35

3.351

2.934

3.827

<0.0001

 

≥30 to <35

2.389

2.130

2.681

 
 

≥25 to <30

1.709

1.538

1.899

 
 

<25 (reference group)

0

.

.

 

Adjusted for Basic Model Parameters

Previous History

     

  Pre-insulin Hypoglycaemia

Yes vs. No

1.113

0.940

1.318

0.4518

  Microvascular disease

Yes vs. No

1.050

0.967

1.141

0.4390

  Macrovascular disease

Yes vs. No

1.021

0.934

1.116

0.4052

Number of OHAs Prior to Insulin Initiation

>2 OHAs

0.853

0.756

0.963

0.0003

2 OHAs

0.928

0.850

1.012

 

1 OHA (reference group)

0

.

.

 

Adjusted for Basic Model Parameters and Number of OHAs Prior to Insulin Initiation

Change in OHA Regimen

Increased

0.965

0.784

1.189

0.0002

 

Decreased

1.150

1.035

1.278

 
 

Unchanged (reference group)

0

.

  

Concomitant OHA Treatment

     

  Metformin

Yes vs. No

1.167

1.066

1.279

0.0009

  Sulphonylureas

Yes vs. No

0.962

0.888

1.043

0.3485

  Glinides

Yes vs. No

0.939

0.848

1.041

0.2315

  α-Glucosidase Inhibitors

Yes vs. No

1.102

0.973

1.248

0.1262

  Thiazolidinediones

Yes vs. No

0.789

0.675

0.921

0.0027

  DPP-IV Inhibitors

Yes vs. No

0.845

0.710

1.005

0.0576

Final Insulin Dose (U/kg)

>0.3

0.871

0.773

0.981

0.0241

 

0.2 to <0.3

0.887

0.791

0.994

 
 

0.1 to <0.2

0.973

0.877

1.079

 
 

< 0.1 (reference group)

0

.

.

 

Mean Insulin Dose (U/kg)

>0.27

0.836

0.740

0.945

0.0193

 

0.20- < 0.27

0.880

0.776

0.997

 
 

0.13- < 0.20

0.944

0.850

1.049

 
 

<0.13 (reference group)

0

   
  1. The effect size is expressed as Odds Ratios (OR) with 95% confidence intervals (CI).