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Table 4 Results of logistic regression models of demographic and study treatment parameters associated with weight loss ≥ 1 kg by final visit

From: Initiation of once daily insulin detemir is not associated with weight gain in patients with type 2 diabetes mellitus: results from an observational study

Parameter Category Odds ratio 95% confidence interval p value
Lower Upper
Basic Model
Baseline HbA1c (%)   0.927 0.905 0.950 <0.0001
Age (years) ≥75 0.902 0.776 1.049 0.6660
  ≥70 to < 75 0.969 0.834 1.126  
  ≥65 to < 70 0.959 0.829 1.109  
  ≥60 to < 65 1.015 0.885 1.165  
  ≥55 to < 60 1.020 0.889 1.171  
  ≥50 to < 55 0.945 0.813 1.098  
  < 50 (reference group) 0 . .  
Gender Female vs. Male 0.916 0.849 0.989 0.0229
Duration of Diabetes (years) >13 0.945 0.844 1.059 0.1681
  >8.5 to ≤13 0.884 0.795 0.983  
  >5 to ≤8.5 0.898 0.807 1.000  
  ≤5 (reference group) 0 . .  
BMI (kg/m2) ≥35 3.351 2.934 3.827 <0.0001
  ≥30 to <35 2.389 2.130 2.681  
  ≥25 to <30 1.709 1.538 1.899  
  <25 (reference group) 0 . .  
Adjusted for Basic Model Parameters
Previous History      
  Pre-insulin Hypoglycaemia Yes vs. No 1.113 0.940 1.318 0.4518
  Microvascular disease Yes vs. No 1.050 0.967 1.141 0.4390
  Macrovascular disease Yes vs. No 1.021 0.934 1.116 0.4052
Number of OHAs Prior to Insulin Initiation >2 OHAs 0.853 0.756 0.963 0.0003
2 OHAs 0.928 0.850 1.012  
1 OHA (reference group) 0 . .  
Adjusted for Basic Model Parameters and Number of OHAs Prior to Insulin Initiation
Change in OHA Regimen Increased 0.965 0.784 1.189 0.0002
  Decreased 1.150 1.035 1.278  
  Unchanged (reference group) 0 .   
Concomitant OHA Treatment      
  Metformin Yes vs. No 1.167 1.066 1.279 0.0009
  Sulphonylureas Yes vs. No 0.962 0.888 1.043 0.3485
  Glinides Yes vs. No 0.939 0.848 1.041 0.2315
  α-Glucosidase Inhibitors Yes vs. No 1.102 0.973 1.248 0.1262
  Thiazolidinediones Yes vs. No 0.789 0.675 0.921 0.0027
  DPP-IV Inhibitors Yes vs. No 0.845 0.710 1.005 0.0576
Final Insulin Dose (U/kg) >0.3 0.871 0.773 0.981 0.0241
  0.2 to <0.3 0.887 0.791 0.994  
  0.1 to <0.2 0.973 0.877 1.079  
  < 0.1 (reference group) 0 . .  
Mean Insulin Dose (U/kg) >0.27 0.836 0.740 0.945 0.0193
  0.20- < 0.27 0.880 0.776 0.997  
  0.13- < 0.20 0.944 0.850 1.049  
  <0.13 (reference group) 0    
  1. The effect size is expressed as Odds Ratios (OR) with 95% confidence intervals (CI).