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Table 2 Glycaemic control, hypoglycaemia, weight, size, lipid profile and blood pressure by BMI subgroup

From: Initiation of once daily insulin detemir is not associated with weight gain in patients with type 2 diabetes mellitus: results from an observational study

  BMI <25 25 ≤ BMI < 30 30 ≤ BMI < 35 BMI ≥ 35
  (n = 3534) (n = 6811) (n = 4218) (n = 2405)
Glycaemic control
HbA1c (%)
  Final visit 7.4 ± 1.2 7.5 ± 1.1 7.7 ± 1.1 7.9 ± 1.3
  Change -1.4 ± 1.7** -1.3 ± 1.5** -1.3 ± 1.5** -1.3 ±1.5**
FBG (mmol/L)
  Final visit 6.8 ± 1.7 7.0 ± 1.6 7.2 ± 1.8 7.7 ± 2.2
  Change -3.0 ± 3.0** -3.0 ± 2.9** -3.2 ± 2.9** -3.2 ± 3.1**
Hypoglycaemia Incidence (events per patient year)
Severe hypoglycaemia
  Pre-insulin 0.057 0.048 0.036 0.028
  Final visit 0.004 0.004 0.010 0.004
  Change -0.053** -0.044** -0.026** -0.024
Minor hypoglycaemia
  Pre-insulin 1.755 1.583 1.341 1.699
  Final visit 2.390 2.009 1.471 1.292
  Change +0.635** +0.426* +0.130* -0.407
Weight (kg)
  Change +0.75 [0.60; 0.90] - 0.16 [-0.26; -0.07] -0.99 [-1.13; -0.84] -1.89 [-2.16; -1.63]
Change in Anthropometric measurements (cm)
  Waist circumference 0.10 [-0.12; 0.32] -0.51 [-0.72; -0.29] -1.23 [-1.57; -0.88] -2.18 [-2.64; -1.73]
  Hip circumference -0.32 [-0.56;- 0.07] -0.67 [-0.88; -0.47] -0.86 [-1.35; -0.36] -1.30 [-1.90; -0.70]
Change in lipid profile (mmol/L)
  Total cholesterol -0.26 [-0.31; -0.20] -0.31 [-0.35; -0.26] -0.34 [-0.40; -0.27] -0.35 [-0.42; -0.27]
  HDH cholesterol +0.01 [-0.01; 0.03] +0.01 [0.00; 0.02] +0.01 [-0.01; 0.03] +0.02 [-0.01; 0.04]
  LDL cholesterol -0.15 [-0.19; -0.10] -0.16 [-0.20; -0.12] -0.18 [-0.24; -0.12] -0.20 [-0.28; -0.13]
  Triglycerides -0.23 [-0.29; -0.17] -0.26 [-0.31; -0.22] -0.34 [-0.40; -0.28] -0.44 [-0.52; -0.37]
Change in blood pressure (mmHg)
  Systolic -3.03 [-3.59; -2.46] -3.77 [-4.23; -3.31] -5.06 [-5.70; -4.43] -5.10 [-5.97; -4.24]
  Diastolic -1.26 [-1.62; -0.91] -2.31 [-2.59; -2.03] -2.22 [-2.60; -1.84] -2.24 [-2.77; -1.71]
  1. Continuous measures are shown as mean ± standard deviation or mean [95% confidence interval].
  2. **p < 0.001.
  3. *p < 0.01.