Initiation of once daily insulin detemir is not associated with weight gain in patients with type 2 diabetes mellitus: results from an observational study

Yale, Jean-François; Damci, Taner; Kaiser, Marcel; Karnieli, Eddy; Khunti, Kamlesh; Liebl, Andreas; Baeres, Florian MM; Svendsen, Anne Louise; Ross, Stuart A

doi:10.1186/1758-5996-5-56

Table 2 Glycaemic control, hypoglycaemia, weight, size, lipid profile and blood pressure by BMI subgroup

From: Initiation of once daily insulin detemir is not associated with weight gain in patients with type 2 diabetes mellitus: results from an observational study

	BMI <25	25 ≤ BMI < 30	30 ≤ BMI < 35	BMI ≥ 35
	(n = 3534)	(n = 6811)	(n = 4218)	(n = 2405)
Glycaemic control
HbA1c (%)
Final visit	7.4 ± 1.2	7.5 ± 1.1	7.7 ± 1.1	7.9 ± 1.3
Change	-1.4 ± 1.7**	-1.3 ± 1.5**	-1.3 ± 1.5**	-1.3 ±1.5**
FBG (mmol/L)
Final visit	6.8 ± 1.7	7.0 ± 1.6	7.2 ± 1.8	7.7 ± 2.2
Change	-3.0 ± 3.0**	-3.0 ± 2.9**	-3.2 ± 2.9**	-3.2 ± 3.1**
Hypoglycaemia Incidence (events per patient year)
Severe hypoglycaemia
Pre-insulin	0.057	0.048	0.036	0.028
Final visit	0.004	0.004	0.010	0.004
Change	-0.053**	-0.044**	-0.026**	-0.024
Minor hypoglycaemia
Pre-insulin	1.755	1.583	1.341	1.699
Final visit	2.390	2.009	1.471	1.292
Change	+0.635**	+0.426*	+0.130*	-0.407
Weight (kg)
Change	+0.75 [0.60; 0.90]	- 0.16 [-0.26; -0.07]	-0.99 [-1.13; -0.84]	-1.89 [-2.16; -1.63]
Change in Anthropometric measurements (cm)
Waist circumference	0.10 [-0.12; 0.32]	-0.51 [-0.72; -0.29]	-1.23 [-1.57; -0.88]	-2.18 [-2.64; -1.73]
Hip circumference	-0.32 [-0.56;- 0.07]	-0.67 [-0.88; -0.47]	-0.86 [-1.35; -0.36]	-1.30 [-1.90; -0.70]
Change in lipid profile (mmol/L)
Total cholesterol	-0.26 [-0.31; -0.20]	-0.31 [-0.35; -0.26]	-0.34 [-0.40; -0.27]	-0.35 [-0.42; -0.27]
HDH cholesterol	+0.01 [-0.01; 0.03]	+0.01 [0.00; 0.02]	+0.01 [-0.01; 0.03]	+0.02 [-0.01; 0.04]
LDL cholesterol	-0.15 [-0.19; -0.10]	-0.16 [-0.20; -0.12]	-0.18 [-0.24; -0.12]	-0.20 [-0.28; -0.13]
Triglycerides	-0.23 [-0.29; -0.17]	-0.26 [-0.31; -0.22]	-0.34 [-0.40; -0.28]	-0.44 [-0.52; -0.37]
Change in blood pressure (mmHg)
Systolic	-3.03 [-3.59; -2.46]	-3.77 [-4.23; -3.31]	-5.06 [-5.70; -4.43]	-5.10 [-5.97; -4.24]
Diastolic	-1.26 [-1.62; -0.91]	-2.31 [-2.59; -2.03]	-2.22 [-2.60; -1.84]	-2.24 [-2.77; -1.71]

Continuous measures are shown as mean ± standard deviation or mean [95% confidence interval].
**p < 0.001.
*p < 0.01.

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ISSN: 1758-5996

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