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Table 1 Clinical characteristics in subjects with different stages of glucose tolerance

From: Glycemic variability in relation to oral disposition index in the subjects with different stages of glucose tolerance

 

NGR

IGM

DM2h

DM

P

N

47

52

61

60

–

Age(year)

45 ± 10

46 ± 13

48 ± 13

44 ± 12

0.093

Female(%)

22(46.8)

21(40.4)

26(51.0)

28(46.7)

0.886

BMI(kg/m2)

24.8 ± 3.4

25.2 ± 2.8

24.7 ± 2.5

25.0 ± 4.4

0.182

SBP(mmHg)

119 ± 12

126 ± 13*

125 ± 15*

132 ± 18*

0.001

DBP(mmHg)

75 ± 10

77 ± 9

79 ± 10*

80 ± 8*

0.015

TG(mmol/L)

1.4(0.8–2.2)

1.5(0.9–2.5)

1.9(1.1–3.3)*‡

1.8(1.4–4.0)*‡

0.002

TC(mmol/L)

4.5 ± 1.2

4.7 ± 1.0

5.1 ± 1.3*

5.3 ± 2.0*‡

0.022

HDL-C(mmol/L)

1.4 ± 0.4

1.2 ± 0.3*

1.1 ± 0.3*

1.1 ± 0.3*

0.013

LDL-C(mmol/L)

2.3 ± 0.8

2.5 ± 0.8

2.8 ± 1.0*‡

2.6 ± 0.7*

0.020

HbA1c(%)

5.3 ± 0.5

6.3 ± 1.1*

7.6 ± 1.6*‡

8.9 ± 1.8*‡§

0.000

ISI

168(122–222)

131(97–203)*

108(74–162)*‡

92(67–142)*‡

0.002

ΔI30/ΔG30

4.5(3.7–5.8)

2.6(1.4–4.4)*

1.6(1.1–3.1)*‡

1.0(0.5–1.9)*‡§

0.000

oral disposition index

745(546–947)

362(271–475)*

203(134–274)*‡

91(70–139)*‡§

0.000

SD(mmol/L)

0.9 ± 0.3

1.5 ± 0.5*

1.9 ± 0.6*‡

2.2 ± 0.6*‡§

0.000

MBG(mmol/L)

5.9 ± 0.5

6.7 ± 0.7*

7.7 ± 1.0*‡

8.7 ± 1.5*‡§

0.000

HBGI

0.8(0.2–1.2)

2.0(1.2–3.7)*

3.8(2.4–5.6)*‡

6.4(3.2–9.5)*‡§

0.000

CONGA1(mmol/L)

1.0 ± 0.2

1.3 ± 0.2*

1.5 ± 0.3*‡

1.8 ± 0.4*‡§

0.000

MODD(mmol/L)

0.9 ± 0.3

1.4 ± 0.4*

1.8 ± 0.7*‡

2.1 ± 0.7*‡§

0.000

MAGE(mmol/L)

2.1 ± 0.6

3.3 ± 1.0*

4.3 ± 1.4*‡

4.8 ± 1.6*‡§

0.000

  1. Normally distributed values in the table are given as the mean ± SD, and the non-normally distributed values are given as the median (25% and 75% interquartiles).
  2. NGR normal glucose regulation, IGM impaired glucose metabolism, DM2h screen-diagnosed diabetes by isolated 2-h glucose, DM newly diagnosed diabetes by both fasting and 2-h glucose.
  3. BMI body mass index, SBP/DBP systolic/diastolic blood pressure, TC total cholesterol, TG triglyceride, HDL-C high density lipoprotein cholesterol, LDL-C low density lipoprotein cholesterol, HbA1c glycosylated hemoglobin A1c, ISI insulin sensitivity index, ΔI30/ΔG30 serum insulin to glucose measured at 30 min, SD standard deviation of blood glucose, MBG mean of blood glucose, HBGI high blood glucose index, CONGA1 continuous overlapping net glycemic action calculated every 1 h, MODD mean of daily differences, MAGE mean amplitude of glycemic excursions.
  4. Sex distribution was compared by Chi-squared test; comparison to NGR: *p < 0.05; comparison to IGM: ‡p < 0.05; comparison to DM2h: §p < 0.05.