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Table 2 Hepatic triglyceride content (hTG), insulin secretion (SI) glucose stimulated insulin response (AIR g ) and disposition index (DI) following the eight months treatment with either hydrochlorothiazide (HCTZ) or Valsartan (mean ± standard error)

From: The metabolic cost of lowering blood pressure with hydrochlorothiazide

  HCTZ Valsartan
Variable Baseline End Baseline End
hTG, f/w, % 7.18 ± 3.30 11.53 ± 4.56 8.29 ± 3.90 8.27 ± 3.38
SI, (x10-5/min pmol/l) 3.72 ± 0.98 2.57 ± 0.02 2.27 ± 0.68 3.51 ± 0.8
AIR g , pmol/l 445 ± 291 466 ± 263 701 ± 608 708 ± 405
DI, (x10-5/min) 1332 ± 399 1191 ± 312 1016 ± 157 2034 ± 566
  1. Of note: DI, SI*AIRg and describes the progression to type 2 diabetes when lowered or improvement of metabolic status when raised [11].