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Table 2 Hepatic triglyceride content (hTG), insulin secretion (SI) glucose stimulated insulin response (AIR g ) and disposition index (DI) following the eight months treatment with either hydrochlorothiazide (HCTZ) or Valsartan (mean ± standard error)

From: The metabolic cost of lowering blood pressure with hydrochlorothiazide

 

HCTZ

Valsartan

Variable

Baseline

End

Baseline

End

hTG, f/w, %

7.18 ± 3.30

11.53 ± 4.56

8.29 ± 3.90

8.27 ± 3.38

SI, (x10-5/min pmol/l)

3.72 ± 0.98

2.57 ± 0.02

2.27 ± 0.68

3.51 ± 0.8

AIR g , pmol/l

445 ± 291

466 ± 263

701 ± 608

708 ± 405

DI, (x10-5/min)

1332 ± 399

1191 ± 312

1016 ± 157

2034 ± 566

  1. Of note: DI, SI*AIRg and describes the progression to type 2 diabetes when lowered or improvement of metabolic status when raised [11].