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Table 2 Feeding behavior, carbohydrate metabolism and blood biochemistry

From: Pleiotropic effects of rosuvastatin on the glucose metabolism and the subcutaneous and visceral adipose tissue behavior in C57Bl/6 mice

Parameters

Groups

Pre-treatment

SC

HF

   

Food intake (g/day)

2.9±0.01

3.7±0.03

   

Energy (kJ/day per mouse)

43.4±0.34

83.7±0.64a

   

OGTT (AUC)

1,174 ±46.55

1,259±45.06a

   

Post-treatment

SC

HF

HF-R10

HF-R20

HF-R40

Food intake (g/day)

2.2±0.01

2.7±0.02 a

2.8±0.02 a,b

2.9±0.02 a,b

3.0±0.01 a,b,c,d

Energy (kJ/day per mouse)

32.6±0.2

60.4±1.1a

63.7±0.5a,b

64.6±0.4a,b

68.5±0.2a,b,c,d

Feed efficiency (kJ/g BM)

1.2±0.02

1.6±0.05a

1.8±0.07 a

1.8±0.05a,b

2.2±0.05 a,b,c,d

Glucose (mg/dL)

109±6.22

149.6±9.9a

134.2±10.4

82.4±7.4 b,c

63.8±6.4 a,b,c

Insulin (mU/ml)

5.85±0.95

20.4±2.0a

20.3±4.1a

16.86±1.20a

14.0±0.32

OGTT (AUC)

990.1±37.8

1,264.2±41.8a

1,236.8±6.0a

1,037.7±34.7b,c

859.3±50.4b,c

HOMA-IR

1.79±0.23

7.51±0.81a

6.66±1.42a

6.53±0.39a

2.04±0.23b,c,d

Serum TC (mg/dL)

103.6±18.1

226.2±16.0a

163.0±16.1b

128.8±12.3b

114.6±7.8b

Serum TG (mg/dL)

51.0±4.6

87.1±4.8a

82.0±7.8a

43.6±8.4b,c

50.0±2.2b,c

ALT (U/L)

15±2.9

115±15.2a

113±19.3a

69.4±9.0a

62.2±8.4a,b

AST (U/L)

272±28.1

289±35.4

283±31.6

191.6±35.5

188.2±33.8

  1. Abbreviations: SC standard rodent chow, HF high-fat diet, HF-R10 10 mg/kg/day of rosuvastatin, HF-R20 20 mg/kg/day of rosuvastatin, HF-R40 40 mg/kg/day of rosuvastatin, OGTT oral glucose tolerance teste, AUC area under the curve, HOMA-IR homeostasis model assessment index for insulin resistance, ALT alanine aminotransferase, AST aspartate transaminase, TC total cholesterol, TG triglyceride. Symbols represent difference with: [a] SC group; [b] HF group; [c] HF-R10 group; [d] HF-R20 group.