|
Main exposure
|
---|
|
Overweighta
|
Obesityb
|
Waist circumference 4thquartilec
|
---|
|
HR (95%CI)
|
HR (95%CI)
|
HR (95%CI)
|
---|
Model 1
|
2.07 (1.45–2.95)
|
6.43 (4.48–9.21)
|
8.30 (5.60–12.28)
|
Model 1’
|
1.27 (0.87–1.86
|
2.67 (1.73–4.13)
|
3.63 (2.28–5.78)
|
Model 2
|
1.23 (0.84–1.81)
|
2.51 (1.63–3.88)
|
3.43 (2.16–5.46)
|
Model 3
|
1.09 (0.74–1.60)
|
1.85 (1.20–2.86)
|
2.54 (1.58–4.08)
|
Model 4
|
1.29 (0.86–1.94)
|
2.48 (1.52–4.05)
|
4.10 (2.34–7.20)
|
Model 5
|
1.17 (0.78–1.76)
|
2.26 (1.37–3.73)
|
3.19 (1.58–6.45)
|
- Model 1: Adjusted for age, study center, ethnicity, gender, and family history of diabetes.
- Model 1’: Model 1 + ln-insulin.
- Model 2: Model 1’ + adiponectin.
- Model 3: Model 2 + inflammation score, C3; oxidized LDL, ICAM-1.
- Model 4: Model 3 + leptin (gender-specific quartiles).
- Model 5: Model 4 + hypertension, non-esterified fatty acids, ln-triglycerides, ln-triglycerides2, HDL, BMI, BMI2, waist-to-hip ratio, (those not already in the model).
- a Hazards ratio of overweight (25 kg/m2 ≤ BMI < 30 kg/m2) versus BMI < 25 kg/m2.
- b Hazards ratio of obese (BMI ≥ 30 kg/m2) versus BMI < 25 kg/m2.
- c 4th vs. 1st quartile. In men: waist circumference >102 cm vs. <91 cm; in women: waist circumference >101 cm vs. <84 cm.