Skip to main content

Table 3 Hazards ratios for diabetes according to obesity levels, adjusting for insulin prior to inflammation markers

From: Chronic inflammation role in the obesity-diabetes association: a case-cohort study

 

Main exposure

 

Overweighta

Obesityb

Waist circumference 4thquartilec

 

HR (95%CI)

HR (95%CI)

HR (95%CI)

Model 1

2.07 (1.45–2.95)

6.43 (4.48–9.21)

8.30 (5.60–12.28)

Model 1’

1.27 (0.87–1.86

2.67 (1.73–4.13)

3.63 (2.28–5.78)

Model 2

1.23 (0.84–1.81)

2.51 (1.63–3.88)

3.43 (2.16–5.46)

Model 3

1.09 (0.74–1.60)

1.85 (1.20–2.86)

2.54 (1.58–4.08)

Model 4

1.29 (0.86–1.94)

2.48 (1.52–4.05)

4.10 (2.34–7.20)

Model 5

1.17 (0.78–1.76)

2.26 (1.37–3.73)

3.19 (1.58–6.45)

  1. Model 1: Adjusted for age, study center, ethnicity, gender, and family history of diabetes.
  2. Model 1’: Model 1 + ln-insulin.
  3. Model 2: Model 1’ + adiponectin.
  4. Model 3: Model 2 + inflammation score, C3; oxidized LDL, ICAM-1.
  5. Model 4: Model 3 + leptin (gender-specific quartiles).
  6. Model 5: Model 4 + hypertension, non-esterified fatty acids, ln-triglycerides, ln-triglycerides2, HDL, BMI, BMI2, waist-to-hip ratio, (those not already in the model).
  7. a Hazards ratio of overweight (25 kg/m2 ≤ BMI < 30 kg/m2) versus BMI < 25 kg/m2.
  8. b Hazards ratio of obese (BMI ≥ 30 kg/m2) versus BMI < 25 kg/m2.
  9. c 4th vs. 1st quartile. In men: waist circumference >102 cm vs. <91 cm; in women: waist circumference >101 cm vs. <84 cm.