Heme oxygenase 1 improves glucoses metabolism and kidney histological alterations in diabetic rats

Table 1 Physiological parameters

Groups	CTL			STZ			STZ + HEME
	day 0	day 30	day 60	day 60	day 30	day 60	day 60	day 30	day 60
BW, g	278 ± 14	364 ± 24	436 ± 17	264 ± 10	241 ± 15*	255 ± 20*	247 ± 5	213 ± 18*	226 ± 18*
Uv, ml	13 ± 2	14 ± 1	12 ± 1	13.1 ± 1	69 ± 11*	57 ± 18*	16 ± 2	83 ± 5*	86 ± 2*
BG, mg/dl	86 ± 4	113 ± 12	109 ± 2	84 ± 4	470 ± 24*	554 ± 29*	80 ± 3	557 ± 27*	338 ± 24*^#
U, mg/dl	45 ± 3	47 ± 4	44 ± 2	48 ± 2	91 ± 11*	88 ± 8*	48 ± 2	70 ± 5*	59 ± 6*^#
ClCr, ml/min	-	-	1.02 ± 0.07	-	-	0.12 ± 0.03*	-	-	0.28 ± 0.02*^#
UA, mg/24h	0.50 ± 0.08	0.33 ± 0.06	0.28 ± 0.04	0.81 ± 0.09	1.67 ± 0.98	3.50 ± 1.04*	0.42 ± 0.05	1.05 ± 0.63	0.85 ± 0.42
UNaV, mEq/24h	0.7 ± 0.1	0.8 ± 0.1	0.7 ± 0.1	0.7 ± 0.1	2.8 ± 0.8*	0.9 ± 0.3	1.0 ± 0.1	2.4 ± 0.5*	1.4 ± 0.2*

Data were expressed as the mean ± SEM. The significance level for a null hypothesis was set at 5% (p < 0.05). BW (body weight), Uv (urinary volume), BG (blood glucose), U (serum urea), ClCr (creatinine clearance), UA (urinary albumin) and UNaV (urinary sodium excretion) were analyzed in CTL, STZ and STZ+HEME groups. (*) versus CTL and (#) versus STZ.

ISSN: 1758-5996