Effect of curcumin on NF-κB activation. Nuclear extracts were prepared and assayed for NF-κB -DNA binding activation by EMSA. The graph was clear reflection of the NF-κB -DNA binding activation among four groups. the level of NF-κB was increased in Group,but decreased by curcumin. Bars represent the mean ± SD from four different groups. : Group I=normal control rats (n=10); : Group II=diabetic control rats (n=10); : Group III=diabetic + curcumin treated rats (n=10); : Group IV=normal + curcumin treated rats (n=10). All values are expressed as the mean ± SD. *p<0.01 (compared to Group I), # p <0.01 (compared to Group II), Δp >0.05 (compared to Group I).