Figure 3

Network related to lipid metabolism in islets cultured at 23 mM glucose concentration. For the explanation of the symbols and letters, see the legend to Figure 2. A total of 19 differentially expressed focus genes were brought into this network with a highly significantly score of 22. The node Srebf1 was identified by the pathway analysis as part of the network, and its differential gene expression was determined subsequently by qRT-PCR. The node Ywhaz was tested for being included in the pathway, but it was not Pioglitazone dependent.