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Table 3 Mean (SD) or median (interquartile interval) values of variables and variation after 9 months of intervention according to IL6 -174 G/C SNP genotypes

From: Associations of the TNF-alpha -308 G/A, IL6 -174 G/C and AdipoQ 45 T/G polymorphisms with inflammatory and metabolic responses to lifestyle intervention in Brazilians at high cardiometabolic risk

  GG (n = 47) GC + CC (n = 86)
  Baseline 9 months p Baseline 9 months p
Energy intake (Kcal/day) 1748(729.6) 1481(588.0) .002 1849(649.8) 1574(549.7) .001
Total physical activity (min/wk) 140(60, 282) 240(70, 330) .001 160(60, 260) 210(70, 290) .001
Weight (kg) 76.9(15.3) 74.7(15.6) .003 78.8(15.7) 77.2(15.3) .001
Waist circumference (cm) 97.2(10.7) 95.7(11.1) .036 99.4(12.8) 98.8(12.3) .161
Fasting glucose (mg/dL) 99.4(11.4) 95.3(11.9) .038 98.9(11.3) 97.1(12.8) .233
Triglycerides (mg/dL) 161.1(60.3) 163.9(84.1) .786 151.5(69.5) 145.3(65.1) .299
Total cholesterol (mg/dL) 198.3(45.8) 209.5(42.7) .122 202.9(42.9) 191.5(43.2)† .011
HDL-c (mg/dL) 44.3(15.5) 45.6(13.6) .446 41.6(10.5) 47.2(12.1) .002
LDL-c (mg/dL) 123.1(42.7) 131.8(37.1) .251 129.4(38.9) 115.5(38.6)† .002
Apolipoprotein B (mg/dL) 95.6(23.2) 85.1(24.5) .003 95.6(22.6) 84.1(24.0) .001
Apolipoprotein A1 (mg/dL) 140.7(22.8) 143.6(24.7) .197 134.3(15.9) 139.8(16.8) .001
Insulin* (uUl/L) 8.1(5.4, 11.4) 5.7(4.0, 9.1) .004 9.7(5.6, 12.1) 7.0(4.3, 10.6) .002
Adiponectin* (ng/dL) 11.8(7.8, 19.3) 13.1(9.8, 19.7) .091 12.1(7.3, 18.6) 16.8(12.4, 19.8) .005
Interleukin 6* (pg/dL) 1.7(0.9, 3.5) 2.8(2.0, 5.4) .007 2.5(1.4, 4.6) 3.6(2.0, 5.8) .027
C-reactive protein* (mg/dL) 0.33(0.10, 0.59) 0.25(0.06, 0.64) .005 0.37(0.19, 0.58) 0.25(0.07, 0.56) .005
TNF-α** (pg/dL) 11.0(9.0, 13.7) 8.9(6.9, 10.5) .017 11.0(9.4, 13.3) 8.8(7.2, 10.6) .016
  1. *Log-transformed for analysis.
  2. **Non-parametric test.
  3. † p < 0.05 versus GG.
  4. TNF-α: Tumor necrosis factor alpha.