Table 2 Mean (SD) or median (interquartile interval) values of variables and variation after 9 months of lifestyle intervention according to SNP TNF −308 G/A genotypes
GG (n = 107) | AA + GA (n = 28) | |||||
|---|---|---|---|---|---|---|
Baseline | 9 months | p | Baseline | 9 months | p | |
Energy intake (Kcal/day) | 1851.6(685.0) | 1555.4(580.6) | .001 | 1633.6(620.9) | 1449.0(488.5) | .006 |
Total physical activity (min/wk) | 167(60, 278) | 205(75, 305) | .002 | 140(30, 210) | 210(60, 400) | .021 |
Weight (kg) | 79.0(15.4) | 77.1(15.2) | .006 | 76.5(16.6) | 74.8(16.9) | .006 |
Waist circumference (cm) | 99.2(12.1) | 98.3(11.7) | .029 | 98.0(13.0) | 96.9(13.6) | .205 |
Fasting glucose (mg/dL) | 97.8(11.1) | 96.2(13.1) | .233 | 103.9(11.2)† | 97.1(9.9) | .007 |
Triglycerides (mg/dL) | 159.1(68.0) | 154.2(74.6) | .428 | 138.2(56.2) | 141.7(61.9) | .689 |
Total cholesterol (mg/dL) | 200.9(42.8) | 197.3(43.3) | .413 | 202.2(47.4) | 197.1(45.9) | .559 |
HDL-c (mg/dL) | 41.7(12.3) | 46.7(13.2) | .020 | 45.5(12.7) | 46.3(10.0) | .778 |
LDL-c (mg/dL) | 127.3(38.9) | 120.1(38.2) | .097 | 126.8(44.6) | 122.4(41.3) | .647 |
Apolipoprotein B (mg/dL) | 95.6(22.4) | 84.8(23.8) | .004 | 95.3(23.4) | 82.5(25.5) | .004 |
Apolipoprotein A1 (mg/dL) | 135.8(17.8) | 140.8(20.1) | .005 | 139.7(21.7) | 142.0(19.0) | .443 |
Insulin* (uUl/L) | 9.8(6.1, 12.0) | 6.9(4.3, 10.5) | .009 | 5.6(4.0, 10.7)† | 5.2(3.1, 8.8) | .151 |
Adiponectin* (ng/dL) | 11.8(7.5, 18.7) | 16.2(11.3, 19.4) | .019 | 11.7(7.3, 19.1) | 16.2(12.2, 20.9) | .020 |
Interleukin 6* (pg/dL) | 2.4(1.3, 3.7) | 3.2(2.0, 5.2) | .013 | 2.4(1.1, 4.9) | 4.2(2.4, 9.4) | .006 |
C-reactive protein* (mg/dL) | 0.37(0.19, 0.59) | 0.25(0.05, 0.55) | .001 | 0.36(0.13, 0.94) | 0.32(0.15, 0.89) | .009 |
TNF-α** (pg/dL) | 10.8(9.0, 13.2) | 8.7(7.2, 10.8) | .020 | 11.3(9.4, 13.9) | 8.9(6.9, 10.2) | .016 |