Figure 3

Control of ‘brite’ (brown) adipocyte development. The scheme depicts the interplay of white adipocytes, myocytes, and mesenchymal precursor cells involved in the (trans-) differentiation process of ‘brite’ and/or brown adipocytes. Abbreviations: BMP7, bone morphogenic protein 7; cAMP, cyclic adenosine monophosphate; CB1, cannabinoid type 1 receptor; C/EBPβ, CCAAT/enhancer binding protein β; cGMP, cyclic guanosine monophosphate; COX2, cyclooxygenase 2; Fndc5, fibronectin type III domain containing 5; NE, norepinephrin; NPs, natriuretic peptides; PGs, prostaglandines; PGC1α, PPARγ-coactivator 1α; PRDM16, PR domain containing 16; T3, triiodothyronine; TZDs, thiazolidinediones; UCP1, uncoupling protein 1.