Effect of the HF–HS diet on plasma levels of insulin and adipokines. Plasma levels of insulin (A), adiponectin (B), and resistin (C) are shown. HF–HS diet: high fat–high sucrose diet. C57BL/6 J mice were fed standard chow diet or the HF–HS diet (milk fat 21% and sucrose 34%) for 2 or 4 weeks. * P < 0.05. ** P < 0.01.