Effect of a high fat diet, CoPP and SnMP on A) vascular reactivity in SHR rats. Aorta was precontracted with phenylephrine (PE) and then exposed to acetylcholine (Ach) in a dose dependent manner (10-9 -10-4 M). *p < 0.05 vs. control, #p < 0.05 vs. HF+ CoPP. B) Superoxide production. * p < 0.01 vs. control, # p < 0.01 vs. HF, † p < 0.01 vs. HF+ CoPP.