Effect of a high fat diet, CoPP and SnMP on coronary resistance and LV function. Isolated heart from control SHR rats after HF diets, HF rats, HF+CoPP and HF+CoPP+SnMP were studied in Langerdorff configuration with a protocol of ischemia/reperfusion. Coronary resistance (CR) (Figure 3A), left ventricular developed pressure (LVDevP) (Figure 3B), dP/dtmax(Figure 3C) and dP/dtmin (Figure 3D) in each stage of ischemia/reperfusion, i.e. baseline (bas), low pressure perfusion (Low P i.e. ischemia) and high pressure i.e.reperfusion (Rep) in SHRs, The results are means ± SE, *p < 0.05 vs. control, # p < 0.05 vs. HF, †p < 0.05 vs. HF+ CoPP.