Effect of a high fat diet and treatment with CoPP and CoPP + SnMP in SHR (n = 14 per group) on A) % of body weight gain. *p < 0.01 vs. control, p < 0.05 vs. high fat B) Blood pressure, which was measured by tail cuff method. *p < 0.01 vs. control, #p < 0.01 vs. HF, †p < 0.01 vs. HF+ CoPP. C) plasma total cholesterol levels. *p < 0.05 vs. control, #p < 0.05 vs HF, †p < 0.05 vs HF+CoPP.