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Table 1 Experimental design

From: L-carnitine ameliorated fatty liver in high-calorie diet/STZ-induced type 2 diabetic mice by improving mitochondrial function

Group

3 weeks old

6 weeks old

9 weeks old

Control

HFD+NS

HFD+NS (CB)

HFD+NS (CB)

DM+NS

HFD+NS

HFD+NS (STZ)

HFD+NS (STZ)

Pre-treat

HFD+LC

HFD+LC (STZ)

HFD+LC (STZ)

DM+LC(L)

HFD+NS

HFD+NS (STZ)

HFD+LC (STZ)

DM+LC(H)

HFD+NS

HFD+NS (STZ)

HFD+LC (STZ)

  1. Control: control group (n = 6), DM+NS: diabetic group (n = 6), pre-treatment: preventive group (n = 6), DM+LC (L): low-dose therapeutic group (125mg/kg, i.g.) (n = 6), DM+LC (H): high-dose therapeutic group (250mg/kg, i.g.) (n = 6). All administrations of LC were given orally. HFD: high-fat diet; STZ: streptozotocin; LC: L-carnitine; CB: citrate buffer. At the age of 6 and 9 weeks, mice were injected twice with STZ or CB, respectively.