Group | 3 weeks old | 6 weeks old | 9 weeks old |
---|
Control | HFD+NS | HFD+NS (CB) | HFD+NS (CB) |
DM+NS | HFD+NS | HFD+NS (STZ) | HFD+NS (STZ) |
Pre-treat | HFD+LC | HFD+LC (STZ) | HFD+LC (STZ) |
DM+LC(L) | HFD+NS | HFD+NS (STZ) | HFD+LC (STZ) |
DM+LC(H) | HFD+NS | HFD+NS (STZ) | HFD+LC (STZ) |
- Control: control group (n = 6), DM+NS: diabetic group (n = 6), pre-treatment: preventive group (n = 6), DM+LC (L): low-dose therapeutic group (125mg/kg, i.g.) (n = 6), DM+LC (H): high-dose therapeutic group (250mg/kg, i.g.) (n = 6). All administrations of LC were given orally. HFD: high-fat diet; STZ: streptozotocin; LC: L-carnitine; CB: citrate buffer. At the age of 6 and 9 weeks, mice were injected twice with STZ or CB, respectively.