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Table 1 Experimental design

From: L-carnitine ameliorated fatty liver in high-calorie diet/STZ-induced type 2 diabetic mice by improving mitochondrial function

Group 3 weeks old 6 weeks old 9 weeks old
Control HFD+NS HFD+NS (CB) HFD+NS (CB)
DM+NS HFD+NS HFD+NS (STZ) HFD+NS (STZ)
Pre-treat HFD+LC HFD+LC (STZ) HFD+LC (STZ)
DM+LC(L) HFD+NS HFD+NS (STZ) HFD+LC (STZ)
DM+LC(H) HFD+NS HFD+NS (STZ) HFD+LC (STZ)
  1. Control: control group (n = 6), DM+NS: diabetic group (n = 6), pre-treatment: preventive group (n = 6), DM+LC (L): low-dose therapeutic group (125mg/kg, i.g.) (n = 6), DM+LC (H): high-dose therapeutic group (250mg/kg, i.g.) (n = 6). All administrations of LC were given orally. HFD: high-fat diet; STZ: streptozotocin; LC: L-carnitine; CB: citrate buffer. At the age of 6 and 9 weeks, mice were injected twice with STZ or CB, respectively.