Summary of our research aims and hypotheses. Our preliminary results suggest that AMPK modulates the adipokine expression and secretion profiles from human adipocytes upon stimulation by inflammatory and/or metabolic factors. Imbalance in the adipokine profile triggers insulin resistance and breast cancer cell growth. Moreover, adipokines alter AMPK activity and modulation of this activity might inhibit the downstream effects of pro-inflammatory and pro-proliferative adipokines (TNFα, IL-6, IL-8, leptin) and improve the effects of anti-inflammatory and anti-proliferative adipokines (adiponectin, IL1-RA) in insulin resistant tissues and breast tumours. AMPK: AMP-dependent protein kinase, LPS: lipopolysaccharides, FFA: free fatty acids, TNFα: tumour necrosis factor α, IL-6: interleukin 6, IL-8: interleukin-8, IL1RA: interleukin-1 receptor antagonist).