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Figure 3 | Diabetology & Metabolic Syndrome

Figure 3

From: Targeting AMP-activated protein kinase in adipocytes to modulate obesity-related adipokine production associated with insulin resistance and breast cancer cell proliferation

Figure 3

AMPKalpha1 prevents the LPS-induced IL-6 and IL-8 adipocytokine expression. Human subcutaneous preadipocyte-derived adipocytes were transfected for 72 h with control non-targeting siRNA pool (Control siRNA) or siRNA pool specifically targeting AMPKalpha1 (AMPKα1 siRNA) and incubated for 24 h with 100 ng/ml LPS. mRNA expression of IL-6 (A) and IL-8 (B) was analysed by quantitative real-time PCR. (*, p < 0.05 vs. LPS in control siRNA cells; ***, p < 0.001 vs. basal in control siRNA cells).

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