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Table 2 Main antidepressants available in Brazil

From: Evaluation of major depression in a routine clinical assessment

Drug Class and Active Ingredient Usual average dose for adults(mg/day) Sedation Anticholinergic Action Orthostatic Hypotension
Tricyclic Antidepressants (TCAs)A
Imipramine 150-200 Moderate Moderate High
Amitriptyline 150-200 High Very high Moderate
Nortriptyline 75-100 Moderate Moderate Lowest of TCAs
Clomipramine 150-200 High High Low
Tetracyclic Antidepressants A
Maprotiline 150-200 Moderate Moderate Low
Monoaminoxidase Inhibitors (MAOIs)
Tranilcipromine 30 - Very low High
Selective serotonin reuptake inhibitors (SSRIs)
Fluoxetine 20-60 Very low None Very low
Paroxetine 20-40 Low Low None
Sertraline 100-150 Low None None
Citalopram 20-40 Low None None
Fluvoxamine 50-150 Low None None
Escitalopram 10-20 Low None None
Serotonin-norepinephrine reuptake inhibitors (SNRIs)
Venlafaxine 75-225 Low None Very lowB
Duloxetine 60 Low Very low Very low
Serotonin-norepinephrine-dopamine-reuptake-inhibitors (SNDRI)
BupropionC 300 Low Very low Very low
Norepinephrine reuptake inhibitor (NRI);
Reboxetine 8-10 Very low Very low Very low
Noradrenergic and specific serotonergic antidepressant (NaSSA).
Mirtazapine 30-45 High Moderate Low
Serotonin reuptake inhibitors and serotinin antagonist (SARI)
TrazodoneD 150-400 High Very low Moderate
  1. A - All cyclic antidepressants have elevated arrhythmogenic potential;
  2. B - Venlafaxin causes dose-dependant blood pressure increase in some individuals;
  3. C - Bupropion reduces convulsive threshold significantly, and it must be avoided in patients with history of syncopes and seizures;
  4. D - Trazodone is associated with cardiac arrhythmia and priapism