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Table 1 Age adjusted association of metabolic syndrome and other related biomarkers in menopausal transition (mean ± SD)

From: Metabolic syndrome in menopausal transition: Isfahan Healthy Heart Program, a population based study

Variables

Pre-menopausal (n = 303)

Menopausal (n = 233)

Post-menopausal (n = 987)

P value*

Age (years)

47.2 ± 2.1

51.5 ± 5.8

61.6 ± 8.5

< 0.001

Systolic blood pressure (mmHg)

120.2 ± 20.2

125.2 ± 23

132.4 ± 22.1

0.030

Diastolic blood pressure (mmHg)

77.8 ± 11.8

80.3 ± 12.8

82.5 ± 11.8

0.008

Fasting plasma glucose (mg/dl)

88.7 ± 29.7

91.2 ± 34

95.1 ± 38.2

0.393§

2 h-post-prandial glucose (mg/dl)

115 ± 53.4

121 ± 67.4

127.3 ± 70.2

0.011§

Total Cholesterol (mg/dl)

209.8 ± 44.6

233.6 ± 54.6

233.3 ± 50.6

< 0.001†

LDL-C (mg/dl)

127.2 ± 38.2

142.8 ± 47.3

142.5 ± 43.5

0.004†

Triglycerides (mg/dl)

176.1 ± 98.9

213.7 ± 118.1

207.8 ± 104.9

< 0.001†

HDL-C (mg/dl)

48.3 ± 10.1

50.4 ± 11

49.5 ± 10.8

0.121

Waist (cm)

97.6 ± 12.5

97.2 ± 13.4

98.5 ± 12.3

0.197

Waist to hip ratio

0.92 ± 0.07

0.93 ± 0.08

0.95 ± 0.07

0.391

Body mass index

28.6 ± 4.7

28.3 ± 5.1

27.6 ± 4.5

0.932

Anti diabetes medication

12(4%)

13(5.6%)

115(11.7%)

0.003

Anti hypertension medication

35(11.6%)

48(20.6%)

324(32.9%)

0.153

Global Dietary Index

0.90 ± 0.23

0.87 ± 0.23

0.84 ± 0.27

0.630

Leisure Time Physical Activity

62.40 ± 82.37

66.19 ± 88.04

62.09 ± 82.54

0.482

  1. * Age adjusted P-value § Adjusted for Anti diabetes medication in addition to age
  2. †Post hoc test did not find significant relationship between early menopausal and Post- Menopausal group