| T1D | T2D | ADM | MODY |
---|---|---|---|---|
Age at onset | Childhood | Puberty | Puberty | Puberty |
Severity at onset | Acute/severe | Moderate to severe, usually insidious | Acute/severe | Mild/insidious |
Insulin secretion | Very low | Varying | Moderately low | Varying |
Insulin sensitivity* | Normal | Reduced | Normal | Normal |
Insulin dependency** | Permanent | No | Varying | No |
Genetic | Polygenic | Polygenic | Autosomal dominant | Autosomal dominant |
Ethnic and racial distribution | All (less frequent in Asians) | Blacks, Hispanics, Asians and Amerindians | Blacks | Caucasians |
Frequency (of all DM types in children and adolescents) | ~80% | 10 - 20% | 5 - 10% | Rare |
Association with Obesity | No | Strong | Varying | No |
Acanthosis nigricans | No | Yes | No | No |
Autoimmunity | Yes | No | No | No |