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Table 1 Central and peripheral sites of action of CB1 receptor antagonists and outcomes of the blockade of the endocannabinoid (EC) system.

From: The multiple functions of the endocannabinoid system: a focus on the regulation of food intake

SITE OF ACTION MECHANISMS OF ACTION BLOCKADE OF EC SYSTEM EFFECTS
Hypothalamic nuclei ↓ food intake body weight waist circumference
Adipose tissue ↑ adiponectin ↓ lipogenesis dyslipidemia insulin resistance
Skeletal muscle ↑ glucose uptake insulin resistance
Liver ↓ lipogenesis dyslipidemia insulin resistance
Gastrointestinal tract ↑ satiety signals body weight waist circumference