Table 1 Central and peripheral sites of action of CB1 receptor antagonists and outcomes of the blockade of the endocannabinoid (EC) system.
From: The multiple functions of the endocannabinoid system: a focus on the regulation of food intake
SITE OF ACTION | MECHANISMS OF ACTION | BLOCKADE OF EC SYSTEM EFFECTS |
|---|---|---|
Hypothalamic nuclei | ↓ food intake | body weight waist circumference |
Adipose tissue | ↑ adiponectin ↓ lipogenesis | dyslipidemia insulin resistance |
Skeletal muscle | ↑ glucose uptake | insulin resistance |
Liver | ↓ lipogenesis | dyslipidemia insulin resistance |
Gastrointestinal tract | ↑ satiety signals | body weight waist circumference |