Table 1 Central and peripheral sites of action of CB1 receptor antagonists and outcomes of the blockade of the endocannabinoid (EC) system.
From: The multiple functions of the endocannabinoid system: a focus on the regulation of food intake
| SITE OF ACTION | MECHANISMS OF ACTION | BLOCKADE OF EC SYSTEM EFFECTS |
|---|---|---|
| Hypothalamic nuclei | ↓ food intake |
body weight waist circumference |
| Adipose tissue |
↑ adiponectin ↓ lipogenesis |
dyslipidemia insulin resistance |
| Skeletal muscle | ↑ glucose uptake | insulin resistance |
| Liver | ↓ lipogenesis |
dyslipidemia insulin resistance |
| Gastrointestinal tract |
↑ satiety signals |
body weight waist circumference |