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Table 8 Partial relation of oral antidiabetic drugs at combination therapy: two substances in a single pill

From: Algorithm for the treatment of type 2 diabetes: a position statement of Brazilian Diabetes Society

Therapeutic classes Chemical Denomination Commercial Denomination Action and Dosage Mechanism
biguanide
+
sulphonylurea
metformin
+
glibenclamide
Glucovance®
Merck
Peripheral action insulin sensitizer (metformin) + long-acting secretagogue of insulin (glibenclamide).
Dosage:
250 mg metformin+1.25 mg glibenclamide 500 mg metformin + 2.5 mg glibenclamide 500 mg metformin + 5 mg glibenclamide.
glitazone
+
biguanides
rosiglitazone
+
metformin
Avandamet®
Glaxo
Combination of two peripheral action insulin sensitizers, with different action
Dosage:
2 mg rosiglitazone + 500 mg metformin
4 mg rosiglitazone + 500 mg metformin.
Incretin mimetic
+
metformin
sitagliptin
+
metformin
Janumet®
MSD
DPP-4inhibitor + peripheral action insulin sensitizer (metformin).
Dosage:
50 mg sitagliptin + 500,
850 or 1,000 mg metformin
Incretin mimetic
+
metformin
vildagliptin
+
metformin
Galvus Met®
Novartis
DPP-4 inhibitor + peripheral action insulin sensitizer (metformin).
Dosage:
50 mg vildagliptin +
500, 850 or 1,000 mg metformin
  1. This table presents only a partial list of commercial medications of various drugs and does not represent a specific recommendation of any commercial brand.