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Table 3 Sequence alignment of the loop domain linking β2 to α2 of YiiP and representative members of the cation diffusion facilitator family.

From: Three-dimensional structure of β-cell-specific zinc transporter, ZnT-8, predicted from the type 2 diabetes-associated gene variant SLC30A8 R325W

CDF homologs Amino acid sequence Residue number
  ----β2--- -L3- ----- α2 --------  
YiiP PTRFIQIHLE MEDSLP LVQAHMVADQVEQAI 286
CzrB PRSFLEFHLV VRGDTP VEEAHRLCDELERAL 269
ZitB EKPVMTLHVQ VI---P PHDHDALLDQIQHYL 275
CzcD GKASLTVHVV NDTA-- VNPEMEVLPELKQML 273
msZnT-8 NQVILSVHVA TA---A SQDSQSVRTGIAQAL 337
hmZnT-2 AQPVLSVHIA IAQN-- -TDAQAVLKTASSRL 293
hmZnT-3 TYHVASAHLA IDST-- -ADPEAVLAEASSRL 357
hmZnT-8 NQVILSAHVA TA---A SRDSQVVRREIAKAL 339
  1. The human ZnT-8 residue R325 is in boldface. YiiP and ZitB are bacterial CDF homologs from Escherichia coli, CzcD from Ralstonia metallidurans, CzrB from Thermus thermophilus, msZnT-8 from Mus musculus (mouse), and ZnT-2, ZnT-3, and ZnT-8 from Homo Sapiens.