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Table 1 Overview of confirmed type 2 diabetes association results in the combined stage 1 and 2 samples for the widely replicated type 2 diabetes-associated variant SLC30A8 R325W (rs13266634).

From: Three-dimensional structure of β-cell-specific zinc transporter, ZnT-8, predicted from the type 2 diabetes-associated gene variant SLC30A8 R325W

Study Total sample size; stage 1+2 (number of cases/controls) OR (95% CI) P -value Ref.
DGI 13,781 (6,529/7,252) 1.07 (1.00-1.16) 0.047 2
WTCCC/UKT2D 13,965 (5,681/8,284) 1.12 (1.05-1.18) 7.0 × 10-5 3
FUSION 4,808 (2,376/2,432) 1.18 (1.09-1.29) 7.0 × 10-5 4
DGI-WTCCC/UKT2D- FUSION (all data) 32,554 (14,586/17,968) 1.12 (1.07-1.16) 5.3 × 10-8 2-4
Icelandic case control* 16,398 (3,836/12,562) 1.15 (1.08-1.22) 3.3 × 10-6 5
France case control 5,511 (2,617/2,894) 1.18 (0.93-1.43)† 1.53 (1.22-1.84)‡ 6.1 × 10-9 6
  1. *Combined European ancestry groups. †Heterozygous. ‡Homozygous.