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Table 1 Overview of confirmed type 2 diabetes association results in the combined stage 1 and 2 samples for the widely replicated type 2 diabetes-associated variant SLC30A8 R325W (rs13266634).

From: Three-dimensional structure of β-cell-specific zinc transporter, ZnT-8, predicted from the type 2 diabetes-associated gene variant SLC30A8 R325W

Study

Total sample size; stage 1+2 (number of cases/controls)

OR (95% CI)

P -value

Ref.

DGI

13,781 (6,529/7,252)

1.07 (1.00-1.16)

0.047

2

WTCCC/UKT2D

13,965 (5,681/8,284)

1.12 (1.05-1.18)

7.0 × 10-5

3

FUSION

4,808 (2,376/2,432)

1.18 (1.09-1.29)

7.0 × 10-5

4

DGI-WTCCC/UKT2D- FUSION (all data)

32,554 (14,586/17,968)

1.12 (1.07-1.16)

5.3 × 10-8

2-4

Icelandic case control*

16,398 (3,836/12,562)

1.15 (1.08-1.22)

3.3 × 10-6

5

France case control

5,511 (2,617/2,894)

1.18 (0.93-1.43)† 1.53 (1.22-1.84)‡

6.1 × 10-9

6

  1. *Combined European ancestry groups. †Heterozygous. ‡Homozygous.