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Table 4 Safety for use of common prescribed drugs for women with diabetes during pregnancy and breastfeeding.

From: Dysglycemias in pregnancy: from diagnosis to treatment. Brazilian consensus statement

Drug Safety for
use during pregnancy
Safety for
use during lactation
Level of
evidence
SWEETENERS    
aspartame, saccharin, acesulfame-K and sucralose Moderately moderately C
ORAL ANTIHYPERGLICEMIC AGENTS    
Glibenclamide No consensus Yes B
Glicazide No No B
Glipizide No Yes B
Glimepiride No No B
Metformin No consensus Yes B
Acarbose No No C
Rosi and pioglitazone No No C
Sita and vildagliptin No No C
Exenatide No No D
INSULIN    
NPH Yes Yes A
Regular Yes Yes A
Lispro Yes Yes B
Aspart Yes Yes B
Gargine No consensus No consensus C
Detemir No consensus No consensus C
ORAL ANTIHYPERLIPIDEMIC AGENTS    
Gemfibrozil No No A
Statins No No A
ANTIHYPERTENSIVE    
Enalapril No With caution A
Captopril No No A
Lisinopril No No A
Methyldopa Yes Yes A
Losartan No With caution A
Candesartan No No A
Hydrochlorothiazide (low doses) Yes Yes C
Calcium channel Inhibitors No Yes C
Beta- blockers(labetalol, metoprolol, propanolol) Yes Yes B
Atenolol No No A
THYROID HORMONES    
Levothyroxine Yes Yes A
ANTITHYROID DRUGS    
Methimazole With caution Yes B
Propiltiouracil Yes Yes B
Iodine No No A
ANTIDEPRESSANTS    
Fluoxetine No No B
Paroxetine With caution Yes B
Tricyclic(amytriptyline, nortriptyline, clomipramine) With caution Yes B
ANTI-INFLAMMATORY DRUGS    
Nimesulide With caution With caution B
Mefenamic acid, ketoprofen, diclofenac, ibuprofen, meloxicam With caution Yes B
Analgesics    
Acetaminophen Yes Yes B
Antibiotics    
Quinolones(norfloxacin, moxifloxacin, ciprofloxacin) No No C